ACSL5 (acyl-CoA synthetase long chain family member 5)

2009-02-01  

Identity

HGNC
ACSL5
LOCATION
10q25.2
LOCUSID
51703
ALIAS
ACS2,ACS5,FACL5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51703
MIM: 605677
HGNC: 16526
Ensembl: ENSG00000197142

Variants:

dbSNP: 51703
ClinVar: 51703
TCGA: ENSG00000197142
COSMIC: ACSL5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197142ENST00000354273Q9ULC5
ENSG00000197142ENST00000354655Q9ULC5
ENSG00000197142ENST00000356116Q9ULC5
ENSG00000197142ENST00000393081Q9ULC5
ENSG00000197142ENST00000433418Q9ULC5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Fatty acid biosynthesisKEGGko00061
Fatty acid degradationKEGGko00071
PPAR signaling pathwayKEGGko03320
Adipocytokine signaling pathwayKEGGko04920
Fatty acid biosynthesisKEGGhsa00061
Fatty acid degradationKEGGhsa00071
PPAR signaling pathwayKEGGhsa03320
Adipocytokine signaling pathwayKEGGhsa04920
PeroxisomeKEGGko04146
PeroxisomeKEGGhsa04146
Metabolic pathwaysKEGGhsa01100
beta-Oxidation, acyl-CoA synthesisKEGGhsa_M00086
beta-Oxidation, acyl-CoA synthesisKEGGM00086
Fatty acid metabolismKEGGhsa01212
Fatty acid metabolismKEGGko01212
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Synthesis of very long-chain fatty acyl-CoAsREACTOMER-HSA-75876
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
188068312009Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.26
176811782007Regulation of enterocyte apoptosis by acyl-CoA synthetase 5 splicing.22
177619452007Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation.20
242221232013Differential expression and prognostic role of selected genes in colorectal cancer patients.19
161984722005Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c.18
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
174951812007Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response.14
174951812007Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response.14

Citation

Dessen P

ACSL5 (acyl-CoA synthetase long chain family member 5)

Atlas Genet Cytogenet Oncol Haematol. 2009-02-01

Online version: http://atlasgeneticsoncology.org/gene/50668/acsl5-(acyl-coa-synthetase-long-chain-family-member-5)