RIOK3 (RIO kinase 3)

2009-02-01  

Identity

HGNC
RIOK3
LOCATION
18q11.2
LOCUSID
8780
ALIAS
SUDD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8780
MIM: 603579
HGNC: 11451
Ensembl: ENSG00000101782

Variants:

dbSNP: 8780
ClinVar: 8780
TCGA: ENSG00000101782
COSMIC: RIOK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101782ENST00000339486O14730
ENSG00000101782ENST00000339486B0YJ89
ENSG00000101782ENST00000577250J3QLP4
ENSG00000101782ENST00000577501O14730
ENSG00000101782ENST00000581585B4E1Q4
ENSG00000101782ENST00000584130J3QQL5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
368808352023RIOK3 promotes mTORC1 activation by facilitating SLC7A2-mediated arginine uptake in pancreatic ductal adenocarcinoma.5
375152522023Alternative Splicing of RIOK3 Engages the Noncanonical NFκB Pathway during Rift Valley Fever Virus Infection.2
368808352023RIOK3 promotes mTORC1 activation by facilitating SLC7A2-mediated arginine uptake in pancreatic ductal adenocarcinoma.5
375152522023Alternative Splicing of RIOK3 Engages the Noncanonical NFκB Pathway during Rift Valley Fever Virus Infection.2
336525972021The Atypical Kinase RIOK3 Limits RVFV Propagation and Is Regulated by Alternative Splicing.5
336525972021The Atypical Kinase RIOK3 Limits RVFV Propagation and Is Regulated by Alternative Splicing.5
292336562018The atypical protein kinase RIOK3 contributes to glioma cell proliferation/survival, migration/invasion and the AKT/mTOR signaling pathway.28
292336562018The atypical protein kinase RIOK3 contributes to glioma cell proliferation/survival, migration/invasion and the AKT/mTOR signaling pathway.28
254864362015Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis.23
258658832015RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response.46
254864362015Hypoxic regulation of RIOK3 is a major mechanism for cancer cell invasion and metastasis.23
258658832015RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response.46
248077082014RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production.25
248077082014RIOK3 is an adaptor protein required for IRF3-mediated antiviral type I interferon production.25
240180502013RIO kinase 3 acts as a SUFU-dependent positive regulator of Hedgehog signaling.11

Citation

Dessen P

RIOK3 (RIO kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-02-01

Online version: http://atlasgeneticsoncology.org/gene/50669/riok3-(rio-kinase-3)