DOK4 (docking protein 4)

2009-03-01  

Identity

HGNC
LOCATION
16q21
LOCUSID
ALIAS
IRS-5,IRS5

Other Information

Locus ID:

NCBI: 55715
MIM: 608333
HGNC: 19868
Ensembl: ENSG00000125170

Variants:

dbSNP: 55715
ClinVar: 55715
TCGA: ENSG00000125170
COSMIC: DOK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125170ENST00000340099Q8TEW6
ENSG00000125170ENST00000340099A0A024R6S2
ENSG00000125170ENST00000561659H3BST9
ENSG00000125170ENST00000562008H3BTI4
ENSG00000125170ENST00000562737A0A1B0GX86
ENSG00000125170ENST00000564378H3BVB4
ENSG00000125170ENST00000566588H3BTI7
ENSG00000125170ENST00000566705H3BN90
ENSG00000125170ENST00000566936H3BQ19
ENSG00000125170ENST00000567175H3BPY9
ENSG00000125170ENST00000567214H3BTK2
ENSG00000125170ENST00000567276H3BTI7
ENSG00000125170ENST00000568617H3BTI7
ENSG00000125170ENST00000569010H3BV67
ENSG00000125170ENST00000569250H3BS85
ENSG00000125170ENST00000569538H3BSK0
ENSG00000125170ENST00000569548Q8TEW6
ENSG00000125170ENST00000569548A0A024R6S2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
RET signalingREACTOMER-HSA-8853659

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
127302412003Two new substrates in insulin signaling, IRS5/DOK4 and IRS6/DOK5.53
168204122006Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase.16
125959002003DOK4 and DOK5: new Dok-related genes expressed in human T cells.8
174434972007DOK4/IRS-5 expression is altered in clear cell renal cell carcinoma.4
194942922009Dok-4 is a novel negative regulator of T cell activation.4
229826782012New insights into Dok-4 PTB domain structure and function.3
190735202008Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells.2

Citation

Dessen P

DOK4 (docking protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50679/dok4-(docking-protein-4)