ARHGAP5 (Rho GTPase activating protein 5)

2009-03-01  

Identity

HGNC
LOCATION
14q12
LOCUSID
ALIAS
GFI2,RhoGAP5,p190-B,p190BRhoGAP
FUSION GENES

Other Information

Locus ID:

NCBI: 394
MIM: 602680
HGNC: 675
Ensembl: ENSG00000100852

Variants:

dbSNP: 394
ClinVar: 394
TCGA: ENSG00000100852
COSMIC: ARHGAP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100852ENST00000345122Q13017
ENSG00000100852ENST00000396582Q13017
ENSG00000100852ENST00000432921A0A0A0MSK6
ENSG00000100852ENST00000433497Q13017
ENSG00000100852ENST00000539826Q13017
ENSG00000100852ENST00000554090G3V360
ENSG00000100852ENST00000555814G3V5I7
ENSG00000100852ENST00000556191G3V444
ENSG00000100852ENST00000556611Q13017
ENSG00000100852ENST00000557643H0YK04

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Leukocyte transendothelial migrationKEGGko04670
Focal adhesionKEGGhsa04510
Leukocyte transendothelial migrationKEGGhsa04670
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
366327412023Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1.3
366327412023Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1.3
361784832022The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay.1
361784832022The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay.1
324834332020Investigation of the role and mechanism of ARHGAP5-mediated colorectal cancer metastasis.13
324834332020Investigation of the role and mechanism of ARHGAP5-mediated colorectal cancer metastasis.13
302500202018SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression.28
302500202018SIRT1 suppresses the migration and invasion of gastric cancer by regulating ARHGAP5 expression.28
281007902017Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions.18
281007902017Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions.18
272310932016VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells.8
272310932016VEGF-A stimulates podosome-mediated collagen-IV proteolysis in microvascular endothelial cells.8
259614342015MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5.33
259614342015MiR-744 functions as a proto-oncogene in nasopharyngeal carcinoma progression and metastasis via transcriptional control of ARHGAP5.33
234747612014Downregulation of miR-486-5p contributes to tumor progression and metastasis by targeting protumorigenic ARHGAP5 in lung cancer.132

Citation

Dessen P

ARHGAP5 (Rho GTPase activating protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50686/arhgap5-(rho-gtpase-activating-protein-5)