CRHR2 (corticotropin releasing hormone receptor 2)

2009-03-01 Affiliation

Identity

HGNC

CRHR2

LOCATION

7p14.3

LOCUSID

1395

ALIAS

CRF-RB,CRF2,CRFR2,HM-CRF

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1395
MIM: 602034
HGNC: 2358
Ensembl: ENSG00000106113

Variants:

dbSNP: 1395
ClinVar: 1395
TCGA: ENSG00000106113
COSMIC: CRHR2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000106113	ENST00000341843	Q13324
ENSG00000106113	ENST00000348438	Q13324
ENSG00000106113	ENST00000423776	F2Z2M6
ENSG00000106113	ENST00000445981	C9JZM9
ENSG00000106113	ENST00000452278	F2Z2M6
ENSG00000106113	ENST00000471646	Q13324
ENSG00000106113	ENST00000471646	A0A090N7T4
ENSG00000106113	ENST00000506074	Q13324

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Synthesis, secretion, and deacylation of Ghrelin	REACTOME	R-HSA-422085
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class B/2 (Secretin family receptors)	REACTOME	R-HSA-373080
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (s) signalling events	REACTOME	R-HSA-418555

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA134687887	selective beta-2-adrenoreceptor agonists	Chemical	ClinicalAnnotation	associated	PD
PA443450	Asthma	Disease	ClinicalAnnotation	associated	PD
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD	17467808
PA448068	salbutamol	Chemical	ClinicalAnnotation	associated	PD
PA449015	citalopram	Chemical	ClinicalAnnotation	associated	PD	17467808

References

Pubmed ID	Year	Title	Citations
19874574	2009	Genetical genomic determinants of alcohol consumption in rats and humans.	93
20351714	2011	Poor replication of candidate genes for major depressive disorder using genome-wide association data.	92
20734064	2010	A large-scale candidate gene association study of age at menarche and age at natural menopause.	38
20673868	2010	A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).	36
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
20966082	2010	Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor.	33
18818748	2008	Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.	31
19527514	2009	Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants.	31
18384079	2008	Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorder.	30
20368512	2010	Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response.	30

Citation

Dessen P

CRHR2 (corticotropin releasing hormone receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50691/crhr2-(corticotropin-releasing-hormone-receptor-2)