SSBP1 (single stranded DNA binding protein 1)

2009-03-01  

Identity

HGNC
SSBP1
LOCATION
7q34
LOCUSID
6742
ALIAS
Mt-SSB,OPA13,SOSS-B1,SSBP,mtSSB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6742
MIM: 600439
HGNC: 11317
Ensembl: ENSG00000106028

Variants:

dbSNP: 6742
ClinVar: 6742
TCGA: ENSG00000106028
COSMIC: SSBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106028ENST00000265304Q04837
ENSG00000106028ENST00000265304A4D1U3
ENSG00000106028ENST00000463093C9K0U8
ENSG00000106028ENST00000465582Q04837
ENSG00000106028ENST00000465582A4D1U3
ENSG00000106028ENST00000467681E7EUY5
ENSG00000106028ENST00000473783C9J8J0
ENSG00000106028ENST00000481508Q04837
ENSG00000106028ENST00000481508A4D1U3
ENSG00000106028ENST00000484178Q04837
ENSG00000106028ENST00000484178A4D1U3
ENSG00000106028ENST00000498107Q04837
ENSG00000106028ENST00000498107A4D1U3
ENSG00000106028ENST00000612337Q04837
ENSG00000106028ENST00000612337A4D1U3

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA replicationKEGGko03030
Mismatch repairKEGGko03430
Homologous recombinationKEGGko03440
DNA replicationKEGGhsa03030
Mismatch repairKEGGhsa03430
Homologous recombinationKEGGhsa03440
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
196053512009HSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response.48
190662012009Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53.40
204344932010Mitochondrial single-stranded DNA binding protein is required for maintenance of mitochondrial DNA and 7S DNA but is not required for mitochondrial nucleoid organisation.32
164282952005PDIP38 associates with proteins constituting the mitochondrial DNA nucleoid.30
212429612011hSSB1 binds and protects p21 from ubiquitin-mediated degradation and positively correlates with p21 in human hepatocellular carcinomas.28
231840572013hSSB1 regulates both the stability and the transcriptional activity of p53.27
183050332008Epstein-Barr virus immediate-early protein Zta co-opts mitochondrial single-stranded DNA binding protein to promote viral and inhibit mitochondrial DNA replication.26
219534572011Reduced stimulation of recombinant DNA polymerase γ and mitochondrial DNA (mtDNA) helicase by variants of mitochondrial single-stranded DNA-binding protein (mtSSB) correlates with defects in mtDNA replication in animal cells.24
197590192009Integrator3, a partner of single-stranded DNA-binding protein 1, participates in the DNA damage response.17
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17

Citation

Dessen P

SSBP1 (single stranded DNA binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50698/ssbp1-(single-stranded-dna-binding-protein-1)