TRA2B (transformer 2 beta homolog)

2009-03-01  

Identity

HGNC
TRA2B
LOCATION
3q27.2
LOCUSID
6434
ALIAS
Htra2-beta,PPP1R156,SFRS10,SRFS10,TRA2-BETA,TRAN2B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6434
MIM: 602719
HGNC: 10781
Ensembl: ENSG00000136527

Variants:

dbSNP: 6434
ClinVar: 6434
TCGA: ENSG00000136527
COSMIC: TRA2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136527ENST00000259043H7BXF3
ENSG00000136527ENST00000342294P62995
ENSG00000136527ENST00000382191P62995
ENSG00000136527ENST00000414862H7C2L4
ENSG00000136527ENST00000453386P62995
ENSG00000136527ENST00000456380P62995

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377051952024Bulk and single-cell alternative splicing analyses reveal roles of TRA2B in myogenic differentiation.2
377051952024Bulk and single-cell alternative splicing analyses reveal roles of TRA2B in myogenic differentiation.2
365495932023Clustered variants in the 5' coding region of TRA2B cause a distinctive neurodevelopmental syndrome.2
368611932023Tra2β Enhances Cell Proliferation by Inducing the Expression of Transcription Factor SP1 in Cervical Cancer.0
365495932023Clustered variants in the 5' coding region of TRA2B cause a distinctive neurodevelopmental syndrome.2
368611932023Tra2β Enhances Cell Proliferation by Inducing the Expression of Transcription Factor SP1 in Cervical Cancer.0
322893782020MicroRNA-330-3p represses the proliferation and invasion of laryngeal squamous cell carcinoma through downregulation of Tra2β-mediated Akt signaling.10
326829512020Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B.62
329649542020Tra2β protects against the degeneration of chondrocytes by inhibiting chondrocyte apoptosis via activating the PI3K/Akt signaling pathway.1
322893782020MicroRNA-330-3p represses the proliferation and invasion of laryngeal squamous cell carcinoma through downregulation of Tra2β-mediated Akt signaling.10
326829512020Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B.62
329649542020Tra2β protects against the degeneration of chondrocytes by inhibiting chondrocyte apoptosis via activating the PI3K/Akt signaling pathway.1
313119542019HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells.27
313119542019HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells.27
291617652018miR-335 inhibited cell proliferation of lung cancer cells by target Tra2β.33

Citation

Dessen P

TRA2B (transformer 2 beta homolog)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50699/tra2b-(transformer-2-beta-homolog)