TRAK1 (trafficking kinesin protein 1)

2009-03-01  

Identity

HGNC
TRAK1
LOCATION
3p22.1
LOCUSID
22906
ALIAS
DEE68,EIEE68,MILT1,OIP106
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 22906
MIM: 608112
HGNC: 29947
Ensembl: ENSG00000182606

Variants:

dbSNP: 22906
ClinVar: 22906
TCGA: ENSG00000182606
COSMIC: TRAK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182606ENST00000327628Q9UPV9
ENSG00000182606ENST00000327628A0A024R2M0
ENSG00000182606ENST00000341421Q9UPV9
ENSG00000182606ENST00000396175C9JC32
ENSG00000182606ENST00000418790F8WDH2
ENSG00000182606ENST00000427771H7C3T3
ENSG00000182606ENST00000449246Q9UPV9
ENSG00000182606ENST00000484786A0A0D9SGH2
ENSG00000182606ENST00000487159A0A0D9SFL5
ENSG00000182606ENST00000613405A0A087X0N0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
233953752013TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites.120
249959782014Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase.83
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
156443242005GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin.60
240923292014DISC1 complexes with TRAK1 and Miro1 to modulate anterograde axonal mitochondrial trafficking.35
186758232008Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking.21
283645492017Deleterious variants in TRAK1 disrupt mitochondrial movement and cause fatal encephalopathy.14
249752732014Changes in vitamin D target gene expression in adipose tissue monitor the vitamin D response of human individuals.10
256531022015Localization of the kinesin adaptor proteins trafficking kinesin proteins 1 and 2 in primary cultures of hippocampal pyramidal and cortical neurons.10
189867592009Identification of TRAK1 (Trafficking protein, kinesin-binding 1) as MGb2-Ag: a novel cancer biomarker.9

Citation

Dessen P

TRAK1 (trafficking kinesin protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50704/trak1-(trafficking-kinesin-protein-1)