DVL2 (dishevelled segment polarity protein 2)

2009-03-01

Identity

HGNC

DVL2

LOCATION

17p13.1

LOCUSID

1856

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1856
MIM: 602151
HGNC: 3086
Ensembl: ENSG00000004975

Variants:

dbSNP: 1856
ClinVar: 1856
TCGA: ENSG00000004975
COSMIC: DVL2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000004975	ENST00000005340	O14641
ENSG00000004975	ENST00000574143	I3L0M7
ENSG00000004975	ENST00000575086	I3L0Z8
ENSG00000004975	ENST00000575458	I3L2N2
ENSG00000004975	ENST00000575756	I3L2W9

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Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Asymmetric localization of PCP proteins	REACTOME	R-HSA-4608870
Basal cell carcinoma	KEGG	ko05217
Basal cell carcinoma	KEGG	hsa05217
Beta-catenin independent WNT signaling	REACTOME	R-HSA-3858494
Breast cancer	KEGG	ko05224
Breast cancer	KEGG	hsa05224
Cargo recognition for clathrin-mediated endocytosis	REACTOME	R-HSA-8856825
Clathrin-mediated endocytosis	REACTOME	R-HSA-8856828
Degradation of DVL	REACTOME	R-HSA-4641258
Disassembly of the destruction complex and recruitment of AXIN to the membrane	REACTOME	R-HSA-4641262

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Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34807493	2022	Dvl2 facilitates the coordination of NF-κB and Wnt signaling to promote colitis-associated colorectal progression.	5
34807493	2022	Dvl2 facilitates the coordination of NF-κB and Wnt signaling to promote colitis-associated colorectal progression.	5
35121725	2022	HBx increases chromatin accessibility and ETV4 expression to regulate dishevelled-2 and promote HCC progression.	12
35121725	2022	HBx increases chromatin accessibility and ETV4 expression to regulate dishevelled-2 and promote HCC progression.	12
35187752	2022	DACT3 has a tumor-inhibiting role in acute myeloid leukemia via the suppression of Wnt/β-catenin signaling by DVL2.	1
35187752	2022	DACT3 has a tumor-inhibiting role in acute myeloid leukemia via the suppression of Wnt/β-catenin signaling by DVL2.	1
36342472	2022	Dishevelled phase separation promotes Wnt signalosome assembly and destruction complex disassembly.	6
36357669	2023	Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism.	2
36357669	2023	Inhibiting von Hippel‒Lindau protein-mediated Dishevelled ubiquitination protects against experimental parkinsonism.	2
36720664	2023	Overexpressions of RHOA, CSNK1A1, DVL2, FZD8, and LRP5 genes enhance gastric cancer development in the presence of Helicobacter pylori.	0

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Citation

Dessen P

DVL2 (dishevelled segment polarity protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50709/dvl2-(dishevelled-segment-polarity-protein-2)