TP53AIP1 (tumor protein p53 regulated apoptosis inducing protein 1)

2009-03-01  

Identity

HGNC
LOCATION
11q24.3
LOCUSID
ALIAS
P53AIP1

Other Information

Locus ID:

NCBI: 63970
MIM: 605426
HGNC: 29984
Ensembl: ENSG00000120471

Variants:

dbSNP: 63970
ClinVar: 63970
TCGA: ENSG00000120471
COSMIC: TP53AIP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120471ENST00000458238Q9HCN2
ENSG00000120471ENST00000527504Q9HCN2
ENSG00000120471ENST00000530777Q9HCN2
ENSG00000120471ENST00000531399Q9HCN2
ENSG00000120471ENST00000602346Q9HCN2

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
p53 signaling pathwayKEGGko04115
ApoptosisKEGGko04210
p53 signaling pathwayKEGGhsa04115
ApoptosisKEGGhsa04210
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Transcription of Cell Death GenesREACTOMER-HSA-5633008
TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseREACTOMER-HSA-6803204

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD
PA445113NeutropeniaDiseaseClinicalAnnotationassociatedPD
PA449165cyclophosphamideChemicalClinicalAnnotationassociatedPD
PA449476epirubicinChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
120191682002p53AIP1 regulates the mitochondrial apoptotic pathway.27
150047242004Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line.22
156573592005Roscovitine-induced up-regulation of p53AIP1 protein precedes the onset of apoptosis in human MCF-7 breast cancer cells.12
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12
147074532003Changes in apoptosis and mitotic index, p53 and Ki67 expression in various types of oral leukoplakia.9
223340682012Apak competes with p53 for direct binding to intron 1 of p53AIP1 to regulate apoptosis.8
192283692009Combination of p53AIP1 and survivin expression is a powerful prognostic marker in non-small cell lung cancer.7
178510562008p53AIP1 expression can be a prognostic marker in non-small cell lung cancer.4
308646842019Extracellular vesicle‑delivered miR‑505‑5p, as a diagnostic biomarker of early lung adenocarcinoma, inhibits cell apoptosis by targeting TP53AIP1.3
182779062008Difference of p53AIP1 mRNA expression in gastric mucosa between patients with gastric cancer and chronic gastritis infected with Helicobacter pylori.2

Citation

Dessen P

TP53AIP1 (tumor protein p53 regulated apoptosis inducing protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50785/tp53aip1-(tumor-protein-p53-regulated-apoptosis-inducing-protein-1)