UCN3 (urocortin 3)

2009-03-01  

Identity

HGNC
UCN3
LOCATION
10p15.1
LOCUSID
114131
ALIAS
SCP,SPC,UCNIII

Other Information

Locus ID:

NCBI: 114131
MIM: 605901
HGNC: 17781
Ensembl: ENSG00000178473

Variants:

dbSNP: 114131
ClinVar: 114131
TCGA: ENSG00000178473
COSMIC: UCN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178473ENST00000380433Q969E3

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
350650982022Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity.5
350650982022Urocortin3: Local inducer of somatostatin release and bellwether of beta cell maturity.5
318935692020Increased urocortin 3 levels are associated with the risk of having type 2 diabetes mellitus.5
318935692020Increased urocortin 3 levels are associated with the risk of having type 2 diabetes mellitus.5
264880732016Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome.3
272623102016Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3.0
272758432016Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.19
277547862016Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing.6
264880732016Increased circulating urocortin-3 levels is associated with polycystic ovary syndrome.3
272623102016Antiamnesic properties of analogs and mimetics of the tripeptide human urocortin 3.0
272758432016Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure.19
277547862016Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing.6
260760352015Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion.144
263504632015Corticotropin Releasing Hormone and Urocortin 3 Stimulate Vascular Endothelial Growth Factor Expression through the cAMP/CREB Pathway.7
260760352015Urocortin3 mediates somatostatin-dependent negative feedback control of insulin secretion.144

Citation

Dessen P

UCN3 (urocortin 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50793/ucn3-(urocortin-3)