DHDH (dihydrodiol dehydrogenase)

2009-03-01  

Identity

HGNC
DHDH
LOCATION
19q13.33
LOCUSID
27294
ALIAS
2DD,HUM2DD
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 27294
MIM: 606377
HGNC: 17887
Ensembl: ENSG00000104808

Variants:

dbSNP: 27294
ClinVar: 27294
TCGA: ENSG00000104808
COSMIC: DHDH

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104808ENST00000221403Q9UQ10
ENSG00000104808ENST00000520557H0YBU7
ENSG00000104808ENST00000522614E5RGT8
ENSG00000104808ENST00000523250E5RFE0

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pentose and glucuronate interconversionsKEGGko00040
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Pentose and glucuronate interconversionsKEGGhsa00040
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
196251762009PTEN identified as important risk factor of chronic obstructive pulmonary disease.12
197732792009Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.6
186004522009Overexpression of dihydrodiol dehydrogenase as a prognostic marker in resected gastric cancer patients.5
191701962009Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.5
113060932001Identity of dimeric dihydrodiol dehydrogenase as NADP(+)-dependent D-xylose dehydrogenase in pig liver.4
233038362013Common variants of the ALDH2 and DHDH genes and the risk of Dupuytren's disease.3
110978392000Roles of His-79 and Tyr-180 of D-xylose/dihydrodiol dehydrogenase in catalytic function.1
247343292013[A coexistence of the Dupuytren's disease and malignant neoplasms: a review].0

Citation

Dessen P

DHDH (dihydrodiol dehydrogenase)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50803/dhdh-(dihydrodiol-dehydrogenase)