DIXDC1 (DIX domain containing 1)

2009-03-01  

Identity

HGNC
LOCATION
11q23.1
LOCUSID
ALIAS
CCD1
FUSION GENES

Other Information

Locus ID:

NCBI: 85458
MIM: 610493
HGNC: 23695
Ensembl: ENSG00000150764

Variants:

dbSNP: 85458
ClinVar: 85458
TCGA: ENSG00000150764
COSMIC: DIXDC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150764ENST00000440460Q155Q3
ENSG00000150764ENST00000529225Q155Q3
ENSG00000150764ENST00000614104A0A087WVH1
ENSG00000150764ENST00000615255Q155Q3

Expression (GTEx)

0
10
20
30
40
50
60

References

Pubmed IDYearTitleCitations
206245902010Dixdc1 is a critical regulator of DISC1 and embryonic cortical development.74
250428062014An AMPK-independent signaling pathway downstream of the LKB1 tumor suppressor controls Snail1 and metastatic potential.47
152629782004The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.14
211894232011Molecular basis of Wnt activation via the DIX domain protein Ccd1.12
195729782009DIXDC1 targets p21 and cyclin D1 via PI3K pathway activation to promote colon cancer cell proliferation.10
238138582014DIXDC1 increases the invasion and migration ability of non-small-cell lung cancer cells via the PI3K-AKT/AP-1 pathway.10
168147452006DIXDC1 isoform, l-DIXDC1, is a novel filamentous actin-binding protein.9
228326592011Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1.8
256482202016DIXDC1 activates the Wnt signaling pathway and promotes gastric cancer cell invasion and metastasis.7
287047992017MicroRNA-539 inhibits glioma cell proliferation and invasion by targeting DIXDC1.6

Citation

Dessen P

DIXDC1 (DIX domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50814/dixdc1-(dix-domain-containing-1)