ARPC1A (actin related protein 2/3 complex subunit 1A)

2009-03-01  

Identity

HGNC
LOCATION
7q22.1
LOCUSID
ALIAS
Arc40,HEL-68,HEL-S-307,SOP2Hs,SOP2L
FUSION GENES

Other Information

Locus ID:

NCBI: 10552
MIM: 604220
HGNC: 703
Ensembl: ENSG00000241685

Variants:

dbSNP: 10552
ClinVar: 10552
TCGA: ENSG00000241685
COSMIC: ARPC1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000241685ENST00000262942Q92747
ENSG00000241685ENST00000262942V9HVZ6
ENSG00000241685ENST00000432786E9PF58

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Regulation of actin cytoskeletonKEGGko04810
Pathogenic Escherichia coli infectionKEGGko05130
Regulation of actin cytoskeletonKEGGhsa04810
Pathogenic Escherichia coli infectionKEGGhsa05130
ShigellosisKEGGhsa05131
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Fcgamma receptor (FCGR) dependent phagocytosisREACTOMER-HSA-2029480
Regulation of actin dynamics for phagocytic cup formationREACTOMER-HSA-2029482
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate WASPs and WAVEsREACTOMER-HSA-5663213
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHB-mediated forward signalingREACTOMER-HSA-3928662
Clathrin-mediated endocytosisREACTOMER-HSA-8856828

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
358711312022ARPC1A is regulated by STAT3 to inhibit ferroptosis and promote prostate cancer progression.4
358711312022ARPC1A is regulated by STAT3 to inhibit ferroptosis and promote prostate cancer progression.4
321307602020Development and validation of hub genes for lymph node metastasis in patients with prostate cancer.15
321307602020Development and validation of hub genes for lymph node metastasis in patients with prostate cancer.15
205709662010Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.181
205709662010Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.181
191456452009Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer.23
191456452009Characterization of the 7q21-q22 amplicon identifies ARPC1A, a subunit of the Arp2/3 complex, as a regulator of cell migration and invasion in pancreatic cancer.23
170729592006Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients.11
170729592006Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients.11

Citation

Dessen P

ARPC1A (actin related protein 2/3 complex subunit 1A)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50815/arpc1a-(actin-related-protein-2-3-complex-subunit-1a)