SPOP (speckle type BTB/POZ protein)

2009-03-01  

Identity

HGNC
SPOP
LOCATION
17q21.33
LOCUSID
8405
ALIAS
BTBD32,NEDMACE,NEDMIDF,NSDVS1,NSDVS2,TEF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8405
MIM: 602650
HGNC: 11254
Ensembl: ENSG00000121067

Variants:

dbSNP: 8405
ClinVar: 8405
TCGA: ENSG00000121067
COSMIC: SPOP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121067ENST00000347630O43791
ENSG00000121067ENST00000393328O43791
ENSG00000121067ENST00000451526D6RA79
ENSG00000121067ENST00000503676O43791
ENSG00000121067ENST00000504102O43791
ENSG00000121067ENST00000504212D6RBR3
ENSG00000121067ENST00000505581D6RDG8
ENSG00000121067ENST00000506399D6RBR3
ENSG00000121067ENST00000507970D6RGZ4
ENSG00000121067ENST00000508805D6RIS7
ENSG00000121067ENST00000509079O43791
ENSG00000121067ENST00000509079D6RDV6
ENSG00000121067ENST00000509869H0Y977
ENSG00000121067ENST00000510476D6RD94
ENSG00000121067ENST00000513080D6RD94
ENSG00000121067ENST00000514121O43791
ENSG00000121067ENST00000514121D6RBH6
ENSG00000121067ENST00000515508D6RFL7
ENSG00000121067ENST00000659760A0A590UJA7
ENSG00000121067ENST00000665825O43791
ENSG00000121067ENST00000671445D6RD94

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Hedgehog signaling pathwayKEGGhsa04340
Cul3-SPOP complexKEGGhsa_M00384
Cul3-SPOP complexKEGGM00384
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'on' stateREACTOMER-HSA-5632684

References

Pubmed IDYearTitleCitations
198187082009Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.153
158974692005Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.115
291603102018Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.90
235593712013Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover.88
245084592014Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants.88
165248762006BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.78
252786112014Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.75
263440952015SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
215772002011Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1.62

Citation

Dessen P

SPOP (speckle type BTB/POZ protein)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50818/spop-(speckle-type-btb-poz-protein)