TRPV4 (transient receptor potential cation channel subfamily V member 4)

2009-03-01  

Identity

HGNC
TRPV4
LOCATION
12q24.11
LOCUSID
59341
ALIAS
BCYM3,CMT2C,HMSN2C,OTRPC4,SMAL,SPSMA,SSQTL1,TRP12,VRL2,VROAC

Other Information

Locus ID:

NCBI: 59341
MIM: 605427
HGNC: 18083
Ensembl: ENSG00000111199

Variants:

dbSNP: 59341
ClinVar: 59341
TCGA: ENSG00000111199
COSMIC: TRPV4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111199ENST00000261740Q9HBA0
ENSG00000111199ENST00000418703Q9HBA0
ENSG00000111199ENST00000536838Q9HBA0
ENSG00000111199ENST00000537083Q9HBA0
ENSG00000111199ENST00000538125F5H6Q4
ENSG00000111199ENST00000541794Q9HBA0
ENSG00000111199ENST00000544971Q9HBA0

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Stimuli-sensing channelsREACTOMER-HSA-2672351
TRP channelsREACTOMER-HSA-3295583
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378895812024Inflammation, lipid dysregulation, and transient receptor potential cation channel subfamily V member 4 signaling perpetuate chronic vulvar pain.1
379262762024TRPV4 in adipose tissue ameliorates diet-induced obesity by promoting white adipocyte browning.0
381129742024Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4.0
382264182024Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension.2
385219592024Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis.0
386123782024Impact of TRP Channels on Extracellular Matrix Remodeling: Focus on TRPV4 and Collagen.0
388559092024TRPV4 mediates IL-1-induced Ca(2+) signaling, ERK activation and MMP expression.1
378895812024Inflammation, lipid dysregulation, and transient receptor potential cation channel subfamily V member 4 signaling perpetuate chronic vulvar pain.1
379262762024TRPV4 in adipose tissue ameliorates diet-induced obesity by promoting white adipocyte browning.0
381129742024Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV4.0
382264182024Fatty acid metabolism promotes TRPV4 activity in lung microvascular endothelial cells in pulmonary arterial hypertension.2
385219592024Inflammation-induced TRPV4 channels exacerbate blood-brain barrier dysfunction in multiple sclerosis.0
386123782024Impact of TRP Channels on Extracellular Matrix Remodeling: Focus on TRPV4 and Collagen.0
388559092024TRPV4 mediates IL-1-induced Ca(2+) signaling, ERK activation and MMP expression.1
360495412023miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4.4

Citation

Dessen P

TRPV4 (transient receptor potential cation channel subfamily V member 4)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50819