KDM4A (lysine demethylase 4A)

2009-04-01  

Identity

HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
JHDM3A,JMJD2,JMJD2A,TDRD14A
FUSION GENES

Other Information

Locus ID:

NCBI: 9682
MIM: 609764
HGNC: 22978
Ensembl: ENSG00000066135

Variants:

dbSNP: 9682
ClinVar: 9682
TCGA: ENSG00000066135
COSMIC: KDM4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000066135ENST00000372396O75164
ENSG00000066135ENST00000463151A0A2R8YDF7
ENSG00000066135ENST00000485249A0A2R8Y7L1

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378738812024The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis.0
378738812024The role of KDM4A-mediated histone methylation on temozolomide resistance in glioma cells through the HUWE1/ROCK2 axis.0
371653082023JMJD2A participates in cytoskeletal remodeling to regulate castration-resistant prostate cancer docetaxel resistance.0
375533622023Carcinogenesis promotion in oral squamous cell carcinoma: KDM4A complex-mediated gene transcriptional suppression by LEF1.1
378709572023SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A.0
371653082023JMJD2A participates in cytoskeletal remodeling to regulate castration-resistant prostate cancer docetaxel resistance.0
375533622023Carcinogenesis promotion in oral squamous cell carcinoma: KDM4A complex-mediated gene transcriptional suppression by LEF1.1
378709572023SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A.0
358330652022Investigation of the Mechanism of hsa_circ_000 1429 Adsorbed miR-205 to Regulate KDM4A and Promote Breast Cancer Metastasis.4
359140742022SUMO Modification of Histone Demethylase KDM4A in Kaposi's Sarcoma-Associated Herpesvirus-Induced Primary Effusion Lymphoma.2
358330652022Investigation of the Mechanism of hsa_circ_000 1429 Adsorbed miR-205 to Regulate KDM4A and Promote Breast Cancer Metastasis.4
359140742022SUMO Modification of Histone Demethylase KDM4A in Kaposi's Sarcoma-Associated Herpesvirus-Induced Primary Effusion Lymphoma.2
334923392021Mechanistic insights into KDM4A driven genomic instability.10
335992782021Histone demethylase KDM4A overexpression improved the efficiency of corrected human tripronuclear zygote development.2
336898832021KDM4A-mediated histone demethylation of SLC7A11 inhibits cell ferroptosis in osteosarcoma.43

Citation

Dessen P

KDM4A (lysine demethylase 4A)

Atlas Genet Cytogenet Oncol Haematol. 2009-04-01

Online version: http://atlasgeneticsoncology.org/gene/50835/kdm4a-(lysine-demethylase-4a)