KDM5C (lysine demethylase 5C)

2009-04-01  

Identity

HGNC
KDM5C
LOCATION
Xp11.22
LOCUSID
8242
ALIAS
DXS1272E,JARID1C,MRX13,MRXJ,MRXSCJ,MRXSJ,SMCX,XE169
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8242
MIM: 314690
HGNC: 11114
Ensembl: ENSG00000126012

Variants:

dbSNP: 8242
ClinVar: 8242
TCGA: ENSG00000126012
COSMIC: KDM5C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126012ENST00000349663F8W7H7
ENSG00000126012ENST00000375379P41229
ENSG00000126012ENST00000375383P41229
ENSG00000126012ENST00000375401P41229
ENSG00000126012ENST00000404049P41229
ENSG00000126012ENST00000428012F8WF56
ENSG00000126012ENST00000429877F8WDK1
ENSG00000126012ENST00000452825P41229

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

References

Pubmed IDYearTitleCitations
382169142024Lysine demethylase 5C inhibits transcription of prefoldin subunit 5 to activate c-Myc signal transduction and colorectal cancer progression.0
382306062024Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.4
382857602024KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity.0
383837802024WNT signalling control by KDM5C during development affects cognition.0
389125812024Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells.0
382169142024Lysine demethylase 5C inhibits transcription of prefoldin subunit 5 to activate c-Myc signal transduction and colorectal cancer progression.0
382306062024Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization.4
382857602024KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity.0
383837802024WNT signalling control by KDM5C during development affects cognition.0
389125812024Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells.0
364342562023Expanding the genetics and phenotypic spectrum of Lysine-specific demethylase 5C (KDM5C): a report of 13 novel variants.4
364959192023Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations.4
366316232023The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes.6
370184012023The histone demethylase KDM5C controls female bone mass by promoting energy metabolism in osteoclasts.4
372099202023Elevated PSPC1 and KDM5C expression indicates poor prognosis in prostate cancer.0

Citation

Dessen P

KDM5C (lysine demethylase 5C)

Atlas Genet Cytogenet Oncol Haematol. 2009-04-01

Online version: http://atlasgeneticsoncology.org/gene/50851