Identity
HGNC
LOCATION
Xp11.22
LOCUSID
ALIAS
DXS1272E,JARID1C,MRX13,MRXJ,MRXSCJ,MRXSJ,SMCX,XE169
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8242
MIM: 314690
HGNC: 11114
Ensembl: ENSG00000126012
Variants:
dbSNP: 8242
ClinVar: 8242
TCGA: ENSG00000126012
COSMIC: KDM5C
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HDMs demethylate histones | REACTOME | R-HSA-3214842 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38216914 | 2024 | Lysine demethylase 5C inhibits transcription of prefoldin subunit 5 to activate c-Myc signal transduction and colorectal cancer progression. | 0 |
| 38230606 | 2024 | Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization. | 4 |
| 38285760 | 2024 | KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity. | 0 |
| 38383780 | 2024 | WNT signalling control by KDM5C during development affects cognition. | 0 |
| 38912581 | 2024 | Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells. | 0 |
| 38216914 | 2024 | Lysine demethylase 5C inhibits transcription of prefoldin subunit 5 to activate c-Myc signal transduction and colorectal cancer progression. | 0 |
| 38230606 | 2024 | Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization. | 4 |
| 38285760 | 2024 | KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity. | 0 |
| 38383780 | 2024 | WNT signalling control by KDM5C during development affects cognition. | 0 |
| 38912581 | 2024 | Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells. | 0 |
| 36434256 | 2023 | Expanding the genetics and phenotypic spectrum of Lysine-specific demethylase 5C (KDM5C): a report of 13 novel variants. | 4 |
| 36495919 | 2023 | Chromatin Sensing by the Auxiliary Domains of KDM5C Regulates Its Demethylase Activity and Is Disrupted by X-linked Intellectual Disability Mutations. | 4 |
| 36631623 | 2023 | The histone demethylase KDM5C functions as a tumor suppressor in AML by repression of bivalently marked immature genes. | 6 |
| 37018401 | 2023 | The histone demethylase KDM5C controls female bone mass by promoting energy metabolism in osteoclasts. | 4 |
| 37209920 | 2023 | Elevated PSPC1 and KDM5C expression indicates poor prognosis in prostate cancer. | 0 |
Citation
Dessen P
KDM5C (lysine demethylase 5C)
Atlas Genet Cytogenet Oncol Haematol. 2009-04-01
Online version: http://atlasgeneticsoncology.org/gene/50851/kdm5c-(lysine-demethylase-5c)
