KDM3B (lysine demethylase 3B)

2009-04-01  

Identity

HGNC
LOCATION
5q31.2
LOCUSID
ALIAS
5qNCA,C5orf7,DIJOS,JMJD1B,NET22
FUSION GENES

Other Information

Locus ID:

NCBI: 51780
MIM: 609373
HGNC: 1337
Ensembl: ENSG00000120733

Variants:

dbSNP: 51780
ClinVar: 51780
TCGA: ENSG00000120733
COSMIC: KDM3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120733ENST00000314358Q7LBC6
ENSG00000120733ENST00000507996H0Y946
ENSG00000120733ENST00000510866H0Y9V5
ENSG00000120733ENST00000542866Q7LBC6

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
318227992020Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer.13
320704142020JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability.8
321078782020Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11.34
327169612020Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes.3
318227992020Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer.13
320704142020JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability.8
321078782020Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11.34
327169612020Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes.3
305144382019Histone demethylase KDM3B regulates the transcriptional network of cell-cycle genes in hepatocarcinoma HepG2 cells.10
309297392019De Novo and Inherited Pathogenic Variants in KDM3B Cause Intellectual Disability, Short Stature, and Facial Dysmorphism.19
305144382019Histone demethylase KDM3B regulates the transcriptional network of cell-cycle genes in hepatocarcinoma HepG2 cells.10
309297392019De Novo and Inherited Pathogenic Variants in KDM3B Cause Intellectual Disability, Short Stature, and Facial Dysmorphism.19
285407462018KDM3B shows tumor-suppressive activity and transcriptionally regulates HOXA1 through retinoic acid response elements in acute myeloid leukemia.19
285407462018KDM3B shows tumor-suppressive activity and transcriptionally regulates HOXA1 through retinoic acid response elements in acute myeloid leukemia.19
254133032015Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B.7

Citation

Dessen P

KDM3B (lysine demethylase 3B)

Atlas Genet Cytogenet Oncol Haematol. 2009-04-01

Online version: http://atlasgeneticsoncology.org/gene/50853/kdm3b-(lysine-demethylase-3b)