Identity
HGNC
LOCATION
5q31.2
LOCUSID
ALIAS
5qNCA,C5orf7,DIJOS,JMJD1B,NET22
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51780
MIM: 609373
HGNC: 1337
Ensembl: ENSG00000120733
Variants:
dbSNP: 51780
ClinVar: 51780
TCGA: ENSG00000120733
COSMIC: KDM3B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000120733 | ENST00000314358 | Q7LBC6 |
| ENSG00000120733 | ENST00000507996 | H0Y946 |
| ENSG00000120733 | ENST00000510866 | H0Y9V5 |
| ENSG00000120733 | ENST00000542866 | Q7LBC6 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Chromatin organization | REACTOME | R-HSA-4839726 |
| Chromatin modifying enzymes | REACTOME | R-HSA-3247509 |
| HDMs demethylate histones | REACTOME | R-HSA-3214842 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31822799 | 2020 | Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer. | 13 |
| 32070414 | 2020 | JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability. | 8 |
| 32107878 | 2020 | Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11. | 34 |
| 32716961 | 2020 | Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes. | 3 |
| 31822799 | 2020 | Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer. | 13 |
| 32070414 | 2020 | JMJD1B, a novel player in histone H3 and H4 processing to ensure genome stability. | 8 |
| 32107878 | 2020 | Histone demethylase KDM3B protects against ferroptosis by upregulating SLC7A11. | 34 |
| 32716961 | 2020 | Histone lysine demethylase 3B (KDM3B) regulates the propagation of autophagy via transcriptional activation of autophagy-related genes. | 3 |
| 30514438 | 2019 | Histone demethylase KDM3B regulates the transcriptional network of cell-cycle genes in hepatocarcinoma HepG2 cells. | 10 |
| 30929739 | 2019 | De Novo and Inherited Pathogenic Variants in KDM3B Cause Intellectual Disability, Short Stature, and Facial Dysmorphism. | 19 |
| 30514438 | 2019 | Histone demethylase KDM3B regulates the transcriptional network of cell-cycle genes in hepatocarcinoma HepG2 cells. | 10 |
| 30929739 | 2019 | De Novo and Inherited Pathogenic Variants in KDM3B Cause Intellectual Disability, Short Stature, and Facial Dysmorphism. | 19 |
| 28540746 | 2018 | KDM3B shows tumor-suppressive activity and transcriptionally regulates HOXA1 through retinoic acid response elements in acute myeloid leukemia. | 19 |
| 28540746 | 2018 | KDM3B shows tumor-suppressive activity and transcriptionally regulates HOXA1 through retinoic acid response elements in acute myeloid leukemia. | 19 |
| 25413303 | 2015 | Transcriptional repression of ANGPT1 by histone H3K9 demethylase KDM3B. | 7 |
Citation
Dessen P
KDM3B (lysine demethylase 3B)
Atlas Genet Cytogenet Oncol Haematol. 2009-04-01
Online version: http://atlasgeneticsoncology.org/gene/50853/kdm3b-(lysine-demethylase-3b)
