FRS2 (fibroblast growth factor receptor substrate 2)

2009-05-01 Affiliation

Identity

HGNC

FRS2

LOCATION

12q15

LOCUSID

10818

ALIAS

FRS1A,FRS2A,FRS2alpha,SNT,SNT-1,SNT1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10818
MIM: 607743
HGNC: 16971
Ensembl: ENSG00000166225

Variants:

dbSNP: 10818
ClinVar: 10818
TCGA: ENSG00000166225
COSMIC: FRS2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000166225	ENST00000397997	Q8WU20
ENSG00000166225	ENST00000397997	L7RTG7
ENSG00000166225	ENST00000547219	F8VZI4
ENSG00000166225	ENST00000547414	F8VZ12
ENSG00000166225	ENST00000548154	F8VYZ7
ENSG00000166225	ENST00000549092	F8VW66
ENSG00000166225	ENST00000549921	Q8WU20
ENSG00000166225	ENST00000549921	L7RTG7
ENSG00000166225	ENST00000550169	A0A0G2JL00
ENSG00000166225	ENST00000550316	F8VP54
ENSG00000166225	ENST00000550389	Q8WU20
ENSG00000166225	ENST00000550389	L7RTG7
ENSG00000166225	ENST00000550937	F8VS98
ENSG00000166225	ENST00000551325	F8VX65

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neurotrophin signaling pathway	KEGG	ko04722
Neurotrophin signaling pathway	KEGG	hsa04722
Proteoglycans in cancer	KEGG	hsa05205
Proteoglycans in cancer	KEGG	ko05205
Disease	REACTOME	R-HSA-1643685
Diseases of signal transduction	REACTOME	R-HSA-5663202
Signaling by FGFR in disease	REACTOME	R-HSA-1226099
Signaling by FGFR1 in disease	REACTOME	R-HSA-5655302
Signaling by FGFR2 in disease	REACTOME	R-HSA-5655253
Signaling by FGFR3 in disease	REACTOME	R-HSA-5655332
Signaling by FGFR4 in disease	REACTOME	R-HSA-5655291
PI3K/AKT Signaling in Cancer	REACTOME	R-HSA-2219528
Constitutive Signaling by Aberrant PI3K in Cancer	REACTOME	R-HSA-2219530
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Signaling by the B Cell Receptor (BCR)	REACTOME	R-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)	REACTOME	R-HSA-1168372
PIP3 activates AKT signaling	REACTOME	R-HSA-1257604
Negative regulation of the PI3K/AKT network	REACTOME	R-HSA-199418
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Role of LAT2/NTAL/LAB on calcium mobilization	REACTOME	R-HSA-2730905
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
GAB1 signalosome	REACTOME	R-HSA-180292
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR1	REACTOME	R-HSA-5654736
Downstream signaling of activated FGFR1	REACTOME	R-HSA-5654687
FRS-mediated FGFR1 signaling	REACTOME	R-HSA-5654693
PI-3K cascade:FGFR1	REACTOME	R-HSA-5654689
Negative regulation of FGFR1 signaling	REACTOME	R-HSA-5654726
Signaling by FGFR2	REACTOME	R-HSA-5654738
Downstream signaling of activated FGFR2	REACTOME	R-HSA-5654696
FRS-mediated FGFR2 signaling	REACTOME	R-HSA-5654700
PI-3K cascade:FGFR2	REACTOME	R-HSA-5654695
Negative regulation of FGFR2 signaling	REACTOME	R-HSA-5654727
Signaling by FGFR3	REACTOME	R-HSA-5654741
Downstream signaling of activated FGFR3	REACTOME	R-HSA-5654708
FRS-mediated FGFR3 signaling	REACTOME	R-HSA-5654706
PI-3K cascade:FGFR3	REACTOME	R-HSA-5654710
Negative regulation of FGFR3 signaling	REACTOME	R-HSA-5654732
Signaling by FGFR4	REACTOME	R-HSA-5654743
Downstream signaling of activated FGFR4	REACTOME	R-HSA-5654716
FRS-mediated FGFR4 signaling	REACTOME	R-HSA-5654712
PI-3K cascade:FGFR4	REACTOME	R-HSA-5654720
Negative regulation of FGFR4 signaling	REACTOME	R-HSA-5654733
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
PI3K Cascade	REACTOME	R-HSA-109704
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
PI3K/AKT activation	REACTOME	R-HSA-198203
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	REACTOME	R-HSA-6811558
Signaling by FGFR3 point mutants in cancer	REACTOME	R-HSA-8853338
Signaling by FGFR3 fusions in cancer	REACTOME	R-HSA-8853334
RET signaling	REACTOME	R-HSA-8853659

References

Pubmed ID	Year	Title	Citations
37264620	2024	Over-expression of microRNA-145 Elevating Autophagy Activities via Downregulating FRS2 Expression.	0
38159618	2024	FRS2 regulated by miR-429 and miR-206 promotes angiogenesis in osteosarcoma.	0
37264620	2024	Over-expression of microRNA-145 Elevating Autophagy Activities via Downregulating FRS2 Expression.	0
38159618	2024	FRS2 regulated by miR-429 and miR-206 promotes angiogenesis in osteosarcoma.	0
36286392	2023	Hsa_circ_0093741 competes with FRS2 for miR-562 binding sites to promote nephroblastoma progression.	0
37458641	2023	Expression of fibroblast growth factor receptor substrate 2 (FRS2) in primary retroperitoneal liposarcoma and its clinical implications.	0
36286392	2023	Hsa_circ_0093741 competes with FRS2 for miR-562 binding sites to promote nephroblastoma progression.	0
37458641	2023	Expression of fibroblast growth factor receptor substrate 2 (FRS2) in primary retroperitoneal liposarcoma and its clinical implications.	0
34159479	2021	Circular RNA circUBR4 regulates ox-LDL-induced proliferation and migration of vascular smooth muscle cells through miR-185-5p/FRS2 axis.	8
34414852	2021	Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) regulates fibroblast growth factor receptor substrate 2 (FRS2) by targeting microRNA (miR)-29-3p in hypertrophic scar fibroblasts.	4
34696768	2021	Expression of FRS2 in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: an immunohistochemical analysis of 182 cases with genetic data.	1
34159479	2021	Circular RNA circUBR4 regulates ox-LDL-induced proliferation and migration of vascular smooth muscle cells through miR-185-5p/FRS2 axis.	8
34414852	2021	Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) regulates fibroblast growth factor receptor substrate 2 (FRS2) by targeting microRNA (miR)-29-3p in hypertrophic scar fibroblasts.	4
34696768	2021	Expression of FRS2 in atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: an immunohistochemical analysis of 182 cases with genetic data.	1
31756773	2020	Genomic coamplification of CDK4/MDM2/FRS2 is associated with very poor prognosis and atypical clinical features in neuroblastoma patients.	14

Citation

Dessen P

FRS2 (fibroblast growth factor receptor substrate 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50862/frs2-(fibroblast-growth-factor-receptor-substrate-2)

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