Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 26257
MIM: 603245
HGNC: 16364
Ensembl: ENSG00000136327
Variants:
dbSNP: 26257
ClinVar: 26257
TCGA: ENSG00000136327
COSMIC: NKX2-8
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000136327 | ENST00000258829 | O15522 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35610207 | 2022 | Nkx2.8 promotes chemosensitivity in bladder urothelial carcinoma via transcriptional repression of MDR1. | 1 |
| 35610207 | 2022 | Nkx2.8 promotes chemosensitivity in bladder urothelial carcinoma via transcriptional repression of MDR1. | 1 |
| 31047858 | 2019 | NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancer. | 29 |
| 31047858 | 2019 | NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancer. | 29 |
| 29311157 | 2018 | Nkx2.8 Inhibits Epithelial-Mesenchymal Transition in Bladder Urothelial Carcinoma via Transcriptional Repression of Twist1. | 9 |
| 29311157 | 2018 | Nkx2.8 Inhibits Epithelial-Mesenchymal Transition in Bladder Urothelial Carcinoma via Transcriptional Repression of Twist1. | 9 |
| 23604637 | 2013 | Nkx2-8 downregulation promotes angiogenesis and activates NF-κB in esophageal cancer. | 26 |
| 23604637 | 2013 | Nkx2-8 downregulation promotes angiogenesis and activates NF-κB in esophageal cancer. | 26 |
| 22223847 | 2012 | The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway. | 24 |
| 22223847 | 2012 | The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway. | 24 |
| 21148747 | 2011 | Both gene amplification and allelic loss occur at 14q13.3 in lung cancer. | 22 |
| 21148747 | 2011 | Both gene amplification and allelic loss occur at 14q13.3 in lung cancer. | 22 |
| 19279207 | 2009 | Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. | 29 |
| 19279207 | 2009 | Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer. | 29 |
| 12167706 | 2002 | Regulation of alpha-fetoprotein expression by Nkx2.8. | 15 |
Citation
Dessen P
NKX2-8 (NK2 homeobox 8)
Atlas Genet Cytogenet Oncol Haematol. 2009-05-01
Online version: http://atlasgeneticsoncology.org/gene/50867/nkx2-8-(nk2-homeobox-8)
