NKX2-8 (NK2 homeobox 8)

2009-05-01  

Identity

HGNC
NKX2-8
LOCATION
14q13.3
LOCUSID
26257
ALIAS
NKX2.8,NKX2H,Nkx2-9

Other Information

Locus ID:

NCBI: 26257
MIM: 603245
HGNC: 16364
Ensembl: ENSG00000136327

Variants:

dbSNP: 26257
ClinVar: 26257
TCGA: ENSG00000136327
COSMIC: NKX2-8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136327ENST00000258829O15522

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
192792072009Characterizing the developmental pathways TTF-1, NKX2-8, and PAX9 in lung cancer.24
236046372013Nkx2-8 downregulation promotes angiogenesis and activates NF-κB in esophageal cancer.18
211487472011Both gene amplification and allelic loss occur at 14q13.3 in lung cancer.16
222238472012The tumor-suppressor gene Nkx2.8 suppresses bladder cancer proliferation through upregulation of FOXO3a and inhibition of the MEK/ERK signaling pathway.16
121677062002Regulation of alpha-fetoprotein expression by Nkx2.8.12
293111572018Nkx2.8 Inhibits Epithelial-Mesenchymal Transition in Bladder Urothelial Carcinoma via Transcriptional Repression of Twist1.5
310478582019NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancer.1

Citation

Dessen P

NKX2-8 (NK2 homeobox 8)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50867/nkx2-8-(nk2-homeobox-8)