KDM6B (lysine demethylase 6B)

2009-05-01  

Identity

HGNC
KDM6B
LOCATION
17p13.1
LOCUSID
23135
ALIAS
JMJD3,NEDCFSA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23135
MIM: 611577
HGNC: 29012
Ensembl: ENSG00000132510

Variants:

dbSNP: 23135
ClinVar: 23135
TCGA: ENSG00000132510
COSMIC: KDM6B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132510ENST00000254846O15054
ENSG00000132510ENST00000448097O15054
ENSG00000132510ENST00000570632I3L0Z0

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HDMs demethylate histonesREACTOMER-HSA-3214842

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378372192024The ATF4-regulated LncRNA MALAT1 promotes odontoblastic differentiation of human dental pulp stem cells via histone demethylase JMJD3: An in vitro study.0
379172392024Targeting lysine demethylase 6B ameliorates ASXL1 truncation-mediated myeloid malignancies in preclinical models.1
382188802024MicroRNA-93-5p regulates odontogenic differentiation and dentin formation via KDM6B.0
382457812024YAP represses intestinal inflammation through epigenetic silencing of JMJD3.0
378372192024The ATF4-regulated LncRNA MALAT1 promotes odontoblastic differentiation of human dental pulp stem cells via histone demethylase JMJD3: An in vitro study.0
379172392024Targeting lysine demethylase 6B ameliorates ASXL1 truncation-mediated myeloid malignancies in preclinical models.1
382188802024MicroRNA-93-5p regulates odontogenic differentiation and dentin formation via KDM6B.0
382457812024YAP represses intestinal inflammation through epigenetic silencing of JMJD3.0
364276982023KDM6B regulates M2 polarization of macrophages by modulating the stability of nuclear β-catenin.1
367915332023Aberrant expression of JMJD3 in SLE promotes B-cell differentiation.1
367974162023KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress.4
372865192023JMJD3 is Involved in Intracranial Aneurysm Development by Regulating DLX2 Expression through H3K27me3 Modification.0
374783142023NOTCH4 potentiates the IL-13 induced genetic program in M2 alternative macrophages through the AP1 and IRF4-JMJD3 axis.2
375740362023E2F1-driven histone demethylase KDM6B enhances thyroid malignancy via manipulating TFEB-dependent autophagy axis.0
376531412023Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade.7

Citation

Dessen P

KDM6B (lysine demethylase 6B)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50868/kdm6b-(lysine-demethylase-6b)