NFIX (nuclear factor I X)

2009-05-01  

Identity

HGNC
NFIX
LOCATION
19p13.13
LOCUSID
4784
ALIAS
CTF,MRSHSS,NF-I/X,NF1-X,NF1A,SOTOS2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4784
MIM: 164005
HGNC: 7788
Ensembl: ENSG00000008441

Variants:

dbSNP: 4784
ClinVar: 4784
TCGA: ENSG00000008441
COSMIC: NFIX

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000008441ENST00000358552C9JWJ8
ENSG00000008441ENST00000360105C9JWJ8
ENSG00000008441ENST00000397661Q14938
ENSG00000008441ENST00000585382K7EMQ5
ENSG00000008441ENST00000585575Q14938
ENSG00000008441ENST00000585575D2DXM9
ENSG00000008441ENST00000586797K7EPU2
ENSG00000008441ENST00000586873K7ESG9
ENSG00000008441ENST00000587260Q14938
ENSG00000008441ENST00000587760Q14938
ENSG00000008441ENST00000588228K7EN08
ENSG00000008441ENST00000590027K7EKH0
ENSG00000008441ENST00000591028K7EJB0
ENSG00000008441ENST00000592199Q14938

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription TerminationREACTOMER-HSA-73980

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
206738632010Distinct effects of allelic NFIX mutations on nonsense-mediated mRNA decay engender either a Sotos-like or a Marshall-Smith syndrome.33
224224522012DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth.33
219534502011A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40.24
165650712006Nuclear factor-1-X regulates astrocyte-specific expression of the alpha1-antichymotrypsin and glial fibrillary acidic protein genes.20
169287562006Interactions between c-Jun, nuclear factor 1, and JC virus promoter sequences: implications for viral tropism.20
194184632009Nuclear factor I isoforms regulate gene expression during the differentiation of human neural progenitors to astrocytes.20
223014652012Missense mutations in the DNA-binding/dimerization domain of NFIX cause Sotos-like features.18
251180282015Malan syndrome: Sotos-like overgrowth with de novo NFIX sequence variants and deletions in six new patients and a review of the literature.17
266956932016The Plasma microRNA miR-1914* and -1915 Suppresses Chemoresistant in Colorectal Cancer Patients by Down-regulating NFIX.16
298995432018MiR-744-5p inducing cell death by directly targeting HNRNPC and NFIX in ovarian cancer cells.13

Citation

Dessen P

NFIX (nuclear factor I X)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50885/nfix-(nuclear-factor-i-x)