MYT1 (myelin transcription factor 1)

2009-05-01  

Identity

HGNC
MYT1
LOCATION
20q13.33
LOCUSID
4661
ALIAS
C20orf36,MTF1,MYTI,NZF2,PLPB1,ZC2H2C1,ZC2HC4A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4661
MIM: 600379
HGNC: 7622
Ensembl: ENSG00000196132

Variants:

dbSNP: 4661
ClinVar: 4661
TCGA: ENSG00000196132
COSMIC: MYT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196132ENST00000328439Q01538
ENSG00000196132ENST00000360149Q6P6D5
ENSG00000196132ENST00000536311Q01538
ENSG00000196132ENST00000622439Q6P6D5
ENSG00000196132ENST00000644172A0A2R8Y3S5
ENSG00000196132ENST00000650655Q01538
ENSG00000196132ENST00000659024Q6P6D5

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
338808802021Novel MYT1 variants expose the complexity of oculo-auriculo-vertebral spectrum genetic mechanisms.2
340112362021Dysregulation of Myt1 expression acts as a potential peripheral biomarker for major depressive disorder and bipolar disorder.0
338808802021Novel MYT1 variants expose the complexity of oculo-auriculo-vertebral spectrum genetic mechanisms.2
340112362021Dysregulation of Myt1 expression acts as a potential peripheral biomarker for major depressive disorder and bipolar disorder.0
322513642020MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex.4
328710522020MYT1 role in the microtia-craniofacial microsomia spectrum.7
322513642020MYT1 attenuates neuroblastoma cell differentiation by interacting with the LSD1/CoREST complex.4
328710522020MYT1 role in the microtia-craniofacial microsomia spectrum.7
305953802019PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene.7
305953802019PICOT binding to the polycomb group protein, EED, alters H3K27 methylation at the MYT1 PRC2 target gene.7
292913462018Analysis of transcriptional activity by the Myt1 and Myt1l transcription factors.12
303126842018Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression.14
292913462018Analysis of transcriptional activity by the Myt1 and Myt1l transcription factors.12
303126842018Myt1 and Myt1l transcription factors limit proliferation in GBM cells by repressing YAP1 expression.14
286128322017A novel de novo mutation in MYT1, the unique OAVS gene identified so far.16

Citation

Dessen P

MYT1 (myelin transcription factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50898/myt1-(myelin-transcription-factor-1)