FABP1 (fatty acid binding protein 1)

2009-05-01  

Identity

HGNC
LOCATION
2p11.2
LOCUSID
ALIAS
FABPL,L-FABP
FUSION GENES

Other Information

Locus ID:

NCBI: 2168
MIM: 134650
HGNC: 3555
Ensembl: ENSG00000163586

Variants:

dbSNP: 2168
ClinVar: 2168
TCGA: ENSG00000163586
COSMIC: FABP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163586ENST00000295834P07148
ENSG00000163586ENST00000295834Q6FGL7
ENSG00000163586ENST00000393750A8MW49

Expression (GTEx)

0
100
200
300
400
500
600
700
800

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
PPAR signaling pathwayKEGGhsa03320
Fat digestion and absorptionKEGGko04975
Fat digestion and absorptionKEGGhsa04975
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysisREACTOMER-HSA-163560
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)REACTOMER-HSA-400206
PPARA activates gene expressionREACTOMER-HSA-1989781

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA446120HypertriglyceridemiaDiseaseClinicalAnnotationassociatedPD15249972
PA449594fenofibrateChemicalClinicalAnnotationassociatedPD15249972

References

Pubmed IDYearTitleCitations
382461682024Unravelling the role of urinary liver-type fatty acid binding protein in histone-induced AKI.0
386170052024Fatty Acid Binding Protein 1 is an Independent Prognostic Biomarker for Gallbladder Cancer with Direct Hepatic Invasion.1
382461682024Unravelling the role of urinary liver-type fatty acid binding protein in histone-induced AKI.0
386170052024Fatty Acid Binding Protein 1 is an Independent Prognostic Biomarker for Gallbladder Cancer with Direct Hepatic Invasion.1
354602762023Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis.31
366018732023Associations of ANGPTL6, DOCK6, FABP1, and PCSK9 single-nucleotide variants with hypercholesterolemia in the Polish population: a cross-sectional study.0
367585112023Fatty acid binding protein 1 (FABP1) and fatty acid binding protein 2 (FABP2) as a link between diabetic nephropathy and subclinical atherosclerosis in children and adolescents with type 1 diabetes.0
370265862023Association between the rs2241883 polymorphism of the fatty acid-binding protein-1 (FABP1) gene and obesity in a population of MASHAD study cohort.1
374998862023Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting ubiquitylation and degradation of FABP1.1
354602762023Intestinal peroxisome proliferator-activated receptor α-fatty acid-binding protein 1 axis modulates nonalcoholic steatohepatitis.31
366018732023Associations of ANGPTL6, DOCK6, FABP1, and PCSK9 single-nucleotide variants with hypercholesterolemia in the Polish population: a cross-sectional study.0
367585112023Fatty acid binding protein 1 (FABP1) and fatty acid binding protein 2 (FABP2) as a link between diabetic nephropathy and subclinical atherosclerosis in children and adolescents with type 1 diabetes.0
370265862023Association between the rs2241883 polymorphism of the fatty acid-binding protein-1 (FABP1) gene and obesity in a population of MASHAD study cohort.1
374998862023Derlin-1 ameliorates nonalcoholic hepatic steatosis by promoting ubiquitylation and degradation of FABP1.1
340826722022FABP1 Gene Variant is Associated with Risk of Metabolic Syndrome.4

Citation

Dessen P

FABP1 (fatty acid binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50906/fabp1-(fatty-acid-binding-protein-1)