GSDMD (gasdermin D)

2009-05-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
DF5L,DFNA5L,FKSG10,GSDMDC1
FUSION GENES

Other Information

Locus ID:

NCBI: 79792
MIM: 617042
HGNC: 25697
Ensembl: ENSG00000104518

Variants:

dbSNP: 79792
ClinVar: 79792
TCGA: ENSG00000104518
COSMIC: GSDMD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104518ENST00000262580P57764
ENSG00000104518ENST00000525208H0YDB0
ENSG00000104518ENST00000525721E9PQ48
ENSG00000104518ENST00000526406P57764
ENSG00000104518ENST00000529854E9PRF1
ENSG00000104518ENST00000533063G3V1A6
ENSG00000104518ENST00000533348E9PQR9
ENSG00000104518ENST00000533888E9PNZ0
ENSG00000104518ENST00000534018E9PIB2

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
263750032015Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.652
273839862016Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.338
266116362015Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion.273
279320732017Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death.182
273391372016GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes.177
274181902016GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.165
291958112018The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages.108
275731742016Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis.91
301435552018Gasdermin D plays a vital role in the generation of neutrophil extracellular traps.45
190513102009Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium.40

Citation

Dessen P

GSDMD (gasdermin D)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50915/gsdmd-(gasdermin-d)