ULBP1 (UL16 binding protein 1)

2009-06-01  

Identity

HGNC
LOCATION
6q25.1
LOCUSID
ALIAS
N2DL-1,NKG2DL1,RAET1I

Other Information

Locus ID:

NCBI: 80329
MIM: 605697
HGNC: 14893
Ensembl: ENSG00000111981

Variants:

dbSNP: 80329
ClinVar: 80329
TCGA: ENSG00000111981
COSMIC: ULBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111981ENST00000229708Q9BZM6

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Natural killer cell mediated cytotoxicityKEGGko04650
Natural killer cell mediated cytotoxicityKEGGhsa04650
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
197984332009HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage response.72
217647622011Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2.59
117779602002UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D and activate multiple signaling pathways in primary NK cells.52
128472602003Effects of human cytomegalovirus infection on ligands for the activating NKG2D receptor of NK cells: up-regulation of UL16-binding protein (ULBP)1 and ULBP2 is counteracted by the viral UL16 protein.47
150517592004Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.38
217568482012Reduced NKG2D ligand expression in hepatocellular carcinoma correlates with early recurrence.33
194148152009Proteasome regulation of ULBP1 transcription.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
202200602010Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells.21
169019032006Transcriptional regulation of ULBP1, a human ligand of the NKG2D receptor.19

Citation

Dessen P

ULBP1 (UL16 binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50936/ulbp1-(ul16-binding-protein-1)