Identity
HGNC
LOCATION
3p21.31
LOCUSID
ALIAS
HLASA,LEURS,PRLTS4,mtLeuRS
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 23395
MIM: 604544
HGNC: 17095
Ensembl: ENSG00000011376
Variants:
dbSNP: 23395
ClinVar: 23395
TCGA: ENSG00000011376
COSMIC: LARS2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 39052101 | 2024 | Exome sequencing reveals pathogenic mutations in the LARS2 and HSD17B4 genes associated with Perrault syndrome and D-bifunctional protein deficiency in Moroccan families. | 0 |
| 39052101 | 2024 | Exome sequencing reveals pathogenic mutations in the LARS2 and HSD17B4 genes associated with Perrault syndrome and D-bifunctional protein deficiency in Moroccan families. | 0 |
| 35750896 | 2023 | Neonatal lactic acidosis explained by LARS2 defect. | 0 |
| 36436798 | 2023 | Lin28a induced mitochondrial dysfunction in human granulosa cells via suppressing LARS2 expression. | 5 |
| 38186093 | 2023 | [Analysis of perrault syndrome caused by pathogenic variants in LARS2 and HARS2 genes]. | 0 |
| 35750896 | 2023 | Neonatal lactic acidosis explained by LARS2 defect. | 0 |
| 36436798 | 2023 | Lin28a induced mitochondrial dysfunction in human granulosa cells via suppressing LARS2 expression. | 5 |
| 38186093 | 2023 | [Analysis of perrault syndrome caused by pathogenic variants in LARS2 and HARS2 genes]. | 0 |
| 35585880 | 2022 | LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells. | 11 |
| 35659337 | 2022 | Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion. | 25 |
| 35585880 | 2022 | LARS2 Regulates Apoptosis via ROS-Mediated Mitochondrial Dysfunction and Endoplasmic Reticulum Stress in Ovarian Granulosa Cells. | 11 |
| 35659337 | 2022 | Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion. | 25 |
| 32442335 | 2020 | The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy. | 12 |
| 32442335 | 2020 | The expanding LARS2 phenotypic spectrum: HLASA, Perrault syndrome with leukodystrophy, and mitochondrial myopathy. | 12 |
| 30737337 | 2019 | Biallelic variants in LARS2 and KARS cause deafness and (ovario)leukodystrophy. | 22 |
Citation
Dessen P
LARS2 (leucyl-tRNA synthetase 2, mitochondrial)
Atlas Genet Cytogenet Oncol Haematol. 2009-06-01
Online version: http://atlasgeneticsoncology.org/gene/50944/lars2-(leucyl-trna-synthetase-2-mitochondrial)
