BRCC3 (BRCA1/BRCA2-containing complex subunit 3)

2009-06-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
BRCC36,C6.1A,CXorf53
FUSION GENES

Other Information

Locus ID:

NCBI: 79184
MIM: 300617
HGNC: 24185
Ensembl: ENSG00000185515

Variants:

dbSNP: 79184
ClinVar: 79184
TCGA: ENSG00000185515
COSMIC: BRCC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185515ENST00000330045P46736
ENSG00000185515ENST00000340647P46736
ENSG00000185515ENST00000369459P46736
ENSG00000185515ENST00000369462P46736
ENSG00000185515ENST00000399026A0A0A0MS96
ENSG00000185515ENST00000399042H9KVA9
ENSG00000185515ENST00000411985X6RJS7
ENSG00000185515ENST00000453705H7C413
ENSG00000185515ENST00000620502A0A087WZR3
ENSG00000185515ENST00000630295A0A0D9SF50

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571
DeubiquitinationREACTOMER-HSA-5688426
Metalloprotease DUBsREACTOMER-HSA-5689901

References

Pubmed IDYearTitleCitations
180773952007Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage.222
192141932009K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1.101
206566902010The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments.45
212821132011NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes.34
215963662011Loss of BRCC3 deubiquitinating enzyme leads to abnormal angiogenesis and is associated with syndromic moyamoya.22
263440972015Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.14
260249152015BRCC3 acts as a prognostic marker in nasopharyngeal carcinoma patients treated with radiotherapy and mediates radiation resistance in vitro.13
171435452007Expression of BRCC3, a novel cell cycle regulated molecule, is associated with increased phospho-ERK and cell proliferation.11
272884112016The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair.11
253377212014Downregulation of BRCA1-BRCA2-containing complex subunit 3 sensitizes glioma cells to temozolomide.10

Citation

Dessen P

BRCC3 (BRCA1/BRCA2-containing complex subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50949/brcc3-(brca1-brca2-containing-complex-subunit-3)