BRCC3 (BRCA1/BRCA2-containing complex subunit 3)

2009-06-01  

Identity

HGNC
BRCC3
LOCATION
Xq28
LOCUSID
79184
ALIAS
BRCC36,C6.1A,CXorf53
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79184
MIM: 300617
HGNC: 24185
Ensembl: ENSG00000185515

Variants:

dbSNP: 79184
ClinVar: 79184
TCGA: ENSG00000185515
COSMIC: BRCC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185515ENST00000330045P46736
ENSG00000185515ENST00000340647P46736
ENSG00000185515ENST00000369459P46736
ENSG00000185515ENST00000369462P46736
ENSG00000185515ENST00000399026A0A0A0MS96
ENSG00000185515ENST00000399042H9KVA9
ENSG00000185515ENST00000411985X6RJS7
ENSG00000185515ENST00000453705H7C413
ENSG00000185515ENST00000620502A0A087WZR3
ENSG00000185515ENST00000630295A0A0D9SF50

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571
DeubiquitinationREACTOMER-HSA-5688426
Metalloprotease DUBsREACTOMER-HSA-5689901

References

Pubmed IDYearTitleCitations
384493912024The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells.0
384705432024Deubiquitinase BRCC3 promotes the migration, invasion and EMT progression of colon adenocarcinoma by stabilizing MET expression.0
385444742024BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome.1
384493912024The deubiquitinase BRCC3 increases the stability of ZEB1 and promotes the proliferation and metastasis of triple-negative breast cancer cells.0
384705432024Deubiquitinase BRCC3 promotes the migration, invasion and EMT progression of colon adenocarcinoma by stabilizing MET expression.0
385444742024BRCC3 mediates inflammation and pyroptosis in cerebral ischemia/reperfusion injury by activating the NLRP6 inflammasome.1
378872752023Identification of BRCC3 and BRCA1 as Regulators of TAZ Stability and Activity.0
378872752023Identification of BRCC3 and BRCA1 as Regulators of TAZ Stability and Activity.0
355035842022Identification and Verification of the Ability of Cdk5 to Phosphorylate Deubiquitinating Enzyme BRCC3 In Vitro.0
355035842022Identification and Verification of the Ability of Cdk5 to Phosphorylate Deubiquitinating Enzyme BRCC3 In Vitro.0
326734282021BRCC36 functions noncatalytically to promote antiviral response by maintaining STAT1 protein stability.1
331070212021ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2.6
326734282021BRCC36 functions noncatalytically to promote antiviral response by maintaining STAT1 protein stability.1
331070212021ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its degradation mediated by the E3 ubiquitin ligase WWP2.6
315760052020Functional characterization of BRCC3 mutations in acute myeloid leukemia with t(8;21)(q22;q22.1).12

Citation

Dessen P

BRCC3 (BRCA1/BRCA2-containing complex subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50949/brcc3-(brca1-brca2-containing-complex-subunit-3)