EYA3 (EYA transcriptional coactivator and phosphatase 3)

2009-06-01  

Identity

HGNC
EYA3
LOCATION
1p35.3
LOCUSID
2140
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2140
MIM: 601655
HGNC: 3521
Ensembl: ENSG00000158161

Variants:

dbSNP: 2140
ClinVar: 2140
TCGA: ENSG00000158161
COSMIC: EYA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158161ENST00000373863Q99504
ENSG00000158161ENST00000373864B1APR7
ENSG00000158161ENST00000373871Q99504
ENSG00000158161ENST00000436342Q99504
ENSG00000158161ENST00000540618Q99504

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
375076372023Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance.1
375076372023Identification of novel mutations in EYA3 and EFTUD2 in a family with craniofacial microsomia: evidence of digenic inheritance.1
334758612021A recurrent missense variant in EYA3 gene is associated with oculo-auriculo-vertebral spectrum.10
344190702021Circular RNA CircEYA3 induces energy production to promote pancreatic ductal adenocarcinoma progression through the miR-1294/c-Myc axis.31
334758612021A recurrent missense variant in EYA3 gene is associated with oculo-auriculo-vertebral spectrum.10
344190702021Circular RNA CircEYA3 induces energy production to promote pancreatic ductal adenocarcinoma progression through the miR-1294/c-Myc axis.31
318471832019Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation.5
318471832019Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation.5
294406622018WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton.12
295353592018Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression.43
294406622018WDR1 is a novel EYA3 substrate and its dephosphorylation induces modifications of the cellular actin cytoskeleton.12
295353592018Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression.43
243676762013Structure-activity relationships of benzbromarone metabolites and derivatives as EYA inhibitory anti-angiogenic agents.20
243676762013Structure-activity relationships of benzbromarone metabolites and derivatives as EYA inhibitory anti-angiogenic agents.20
227233082012EWS/FLI1 regulates EYA3 in Ewing sarcoma via modulation of miRNA-708, resulting in increased cell survival and chemoresistance.58

Citation

Dessen P

EYA3 (EYA transcriptional coactivator and phosphatase 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50951/eya3-(eya-transcriptional-coactivator-and-phosphatase-3)