RNF168 (ring finger protein 168)

2009-06-01  

Identity

HGNC
LOCATION
3q29
LOCUSID
ALIAS
RIDL,hRNF168
FUSION GENES

Other Information

Locus ID:

NCBI: 165918
MIM: 612688
HGNC: 26661
Ensembl: ENSG00000163961

Variants:

dbSNP: 165918
ClinVar: 165918
TCGA: ENSG00000163961
COSMIC: RNF168

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163961ENST00000318037Q8IYW5
ENSG00000163961ENST00000437070F8WD60

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
SUMO E3 ligases SUMOylate target proteinsREACTOMER-HSA-3108232
SUMOylation of DNA damage response and repair proteinsREACTOMER-HSA-3108214
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
Processing of DNA double-strand break endsREACTOMER-HSA-5693607
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571

References

Pubmed IDYearTitleCitations
367710812023Emerging Roles of RNF168 in Tumor Progression.2
369443182023Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis.2
373506662023SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer.11
374514802023UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair.0
375038422023The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair.2
367710812023Emerging Roles of RNF168 in Tumor Progression.2
369443182023Degradation of Ubiquitin-Editing Enzyme A20 following Autophagy Activation Promotes RNF168 Nuclear Translocation and NF-κB Activation in Lupus Nephritis.2
373506662023SENP1 Decreases RNF168 Phase Separation to Promote DNA Damage Repair and Drug Resistance in Colon Cancer.11
374514802023UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair.0
375038422023The HDAC6-RNF168 axis regulates H2A/H2A.X ubiquitination to enable double-strand break repair.2
337972062022New answers to the old RIDDLE: RNF168 and the DNA damage response pathway.6
348738292022RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination.2
352246902022Defective repair of topoisomerase I induced chromosomal damage in Huntington's disease.3
337972062022New answers to the old RIDDLE: RNF168 and the DNA damage response pathway.6
348738292022RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination.2

Citation

Dessen P

RNF168 (ring finger protein 168)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50960/rnf168