TMEM8B (transmembrane protein 8B)

2009-06-01  

Identity

HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
C9orf127,FP588,LINC00950,NAG-5,NAG5,NGX6,NGX6a

Other Information

Locus ID:

NCBI: 51754
MIM: 616888
HGNC: 21427
Ensembl: ENSG00000137103

Variants:

dbSNP: 51754
ClinVar: 51754
TCGA: ENSG00000137103
COSMIC: TMEM8B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137103ENST00000377988A6NDV4
ENSG00000137103ENST00000377991A6NDV4
ENSG00000137103ENST00000377996A6NDV4
ENSG00000137103ENST00000439587A6NDV4
ENSG00000137103ENST00000643932A0A2R8Y2M5
ENSG00000137103ENST00000650015A6NDV4

Expression (GTEx)

0
10
20
30
40
50
60
70

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
333000772021Nasopharyngeal carcinoma‑associated gene 6 inhibits cell viability, migration, invasion and induces apoptosis in osteosarcoma cells by inactivating the Wnt/β‑catenin signaling pathway.1
333000772021Nasopharyngeal carcinoma‑associated gene 6 inhibits cell viability, migration, invasion and induces apoptosis in osteosarcoma cells by inactivating the Wnt/β‑catenin signaling pathway.1
292437792017Effects of NGX6 expression on proliferation and invasion of nasopharyngeal carcinoma cells and survival of patients.2
292437792017Effects of NGX6 expression on proliferation and invasion of nasopharyngeal carcinoma cells and survival of patients.2
268805832016Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers.2
268805832016Tumor suppressor NGX6 inhibits the growth and metastasis of multiple cancers.2
258820972015Analysis of functional variants reveals new candidate genes associated with alexithymia.7
262615222015Association of ultrasonographic features with NGX6 expression and prognosis in invasive ductal breast carcinoma.2
258820972015Analysis of functional variants reveals new candidate genes associated with alexithymia.7
262615222015Association of ultrasonographic features with NGX6 expression and prognosis in invasive ductal breast carcinoma.2
243382742014DNA promoter and histone H3 methylation downregulate NGX6 in gastric cancer cells.4
250299112014Egr-1 regulates the transcription of NGX6 gene through a Sp1/Egr-1 overlapping site in the promoter.7
253784012014NGX6a is degraded through a proteasome-dependent pathway without ubiquitination mediated by ezrin, a cytoskeleton-membrane linker.0
243382742014DNA promoter and histone H3 methylation downregulate NGX6 in gastric cancer cells.4
250299112014Egr-1 regulates the transcription of NGX6 gene through a Sp1/Egr-1 overlapping site in the promoter.7

Citation

Dessen P

TMEM8B (transmembrane protein 8B)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50966/tmem8b-(transmembrane-protein-8b)