Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 4200
MIM: 154270
HGNC: 6984
Ensembl: ENSG00000082212
Variants:
dbSNP: 4200
ClinVar: 4200
TCGA: ENSG00000082212
COSMIC: ME2
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Pyruvate metabolism | KEGG | ko00620 |
| Pyruvate metabolism | KEGG | hsa00620 |
| Carbon metabolism | KEGG | hsa01200 |
| Carbon metabolism | KEGG | ko01200 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38007551 | 2024 | SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration. | 1 |
| 38007551 | 2024 | SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration. | 1 |
| 35228743 | 2022 | Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate. | 15 |
| 35228743 | 2022 | Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate. | 15 |
| 32564485 | 2020 | Expression levels of SIX1, ME2, and AP2M1 in adenoid cystic carcinoma and mucoepidermoid carcinoma. | 6 |
| 32564485 | 2020 | Expression levels of SIX1, ME2, and AP2M1 in adenoid cystic carcinoma and mucoepidermoid carcinoma. | 6 |
| 30719716 | 2019 | Replication, reanalysis, and gene expression: ME2 and genetic generalized epilepsy. | 6 |
| 30719716 | 2019 | Replication, reanalysis, and gene expression: ME2 and genetic generalized epilepsy. | 6 |
| 28099419 | 2017 | Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. | 127 |
| 28174172 | 2017 | Collateral Lethality in Pancreatic Cancer. | 0 |
| 28099419 | 2017 | Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. | 127 |
| 28174172 | 2017 | Collateral Lethality in Pancreatic Cancer. | 0 |
| 26381116 | 2016 | Expression of Malic Enzymes in Sebaceous Lesions. | 1 |
| 27166188 | 2016 | The mechanisms of malic enzyme 2 in the tumorigenesis of human gliomas. | 15 |
| 26381116 | 2016 | Expression of Malic Enzymes in Sebaceous Lesions. | 1 |
Citation
Dessen P
ME2 (malic enzyme 2)
Atlas Genet Cytogenet Oncol Haematol. 2009-06-01
Online version: http://atlasgeneticsoncology.org/gene/50969/me2-(malic-enzyme-2)
