ATP6V0C (ATPase H+ transporting V0 subunit c)

2009-06-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
ATP6C,ATP6L,ATPL,VATL,VPPC,Vma3
FUSION GENES

Other Information

Locus ID:

NCBI: 527
MIM: 108745
HGNC: 855
Ensembl: ENSG00000185883

Variants:

dbSNP: 527
ClinVar: 527
TCGA: ENSG00000185883
COSMIC: ATP6V0C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185883ENST00000330398P27449
ENSG00000185883ENST00000564973H3BNI4
ENSG00000185883ENST00000565223H3BNI4
ENSG00000185883ENST00000568562H3BMY0

Expression (GTEx)

0
100
200
300
400
500
600
700

Pathways

PathwaySourceExternal ID
Oxidative phosphorylationKEGGko00190
Vibrio cholerae infectionKEGGko05110
Epithelial cell signaling in Helicobacter pylori infectionKEGGko05120
Oxidative phosphorylationKEGGhsa00190
Vibrio cholerae infectionKEGGhsa05110
Epithelial cell signaling in Helicobacter pylori infectionKEGGhsa05120
LysosomeKEGGko04142
LysosomeKEGGhsa04142
Metabolic pathwaysKEGGhsa01100
Collecting duct acid secretionKEGGko04966
Collecting duct acid secretionKEGGhsa04966
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
V-type ATPase, eukaryotesKEGGhsa_M00160
V-type ATPase, eukaryotesKEGGM00160
ROS, RNS production in phagocytesREACTOMER-HSA-1222556
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor recyclingREACTOMER-HSA-77387
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Iron uptake and transportREACTOMER-HSA-917937
Transferrin endocytosis and recyclingREACTOMER-HSA-917977
Ion channel transportREACTOMER-HSA-983712
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
198754482010Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.29
192990752009Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells.28
241660502014V-ATPase inhibition by archazolid leads to lysosomal dysfunction resulting in impaired cathepsin B activation in vivo.25
246955742014ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.24
190587892009A common variant in DRD3 receptor is associated with autism spectrum disorder.19
228297662012A cytotoxic type III secretion effector of Vibrio parahaemolyticus targets vacuolar H+-ATPase subunit c and ruptures host cell lysosomes.18
243859032013Systematic microRNA analysis identifies ATP6V0C as an essential host factor for human cytomegalovirus replication.16
242543212014Regulation of endothelial signaling and migration by v-ATPase.14
229912182013A novel tumor metastasis suppressor gene LASS2/TMSG1 interacts with vacuolar ATPase through its homeodomain.9
261105662015AGPAT9 suppresses cell growth, invasion and metastasis by counteracting acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer.9

Citation

Dessen P

ATP6V0C (ATPase H+ transporting V0 subunit c)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50975/atp6v0c-(atpase-h+-transporting-v0-subunit-c)