TUBG1 (tubulin gamma 1)

2009-06-01  

Identity

HGNC
LOCATION
17q21.2
LOCUSID
ALIAS
CDCBM4,GCP-1,TUBG,TUBGCP1
FUSION GENES

Other Information

Locus ID:

NCBI: 7283
MIM: 191135
HGNC: 12417
Ensembl: ENSG00000131462

Variants:

dbSNP: 7283
ClinVar: 7283
TCGA: ENSG00000131462
COSMIC: TUBG1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131462ENST00000251413P23258
ENSG00000131462ENST00000589688K7EKE5
ENSG00000131462ENST00000591509K7EIS0

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Recruitment of NuMA to mitotic centrosomesREACTOMER-HSA-380320
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378068482024TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.2
378068482024TuBG1 promotes hepatocellular carcinoma via ATR/P53-apoptosis and cycling pathways.2
367928632023Upregulation of TUBG1 expression promotes hepatocellular carcinoma development.0
376859692023Centrosome Movements Are TUBG1-Dependent.0
367928632023Upregulation of TUBG1 expression promotes hepatocellular carcinoma development.0
376859692023Centrosome Movements Are TUBG1-Dependent.0
334967292021Biochemical reconstitutions reveal principles of human γ-TuRC assembly and function.15
347798592021Microtubule-associated proteins promote microtubule generation in the absence of γ-tubulin in human colon cancer cells.9
334967292021Biochemical reconstitutions reveal principles of human γ-TuRC assembly and function.15
347798592021Microtubule-associated proteins promote microtubule generation in the absence of γ-tubulin in human colon cancer cells.9
327322892020Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles.2
327322892020Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles.2
300101742019Expression of γ-tubulin in non-small cell lung cancer and effect on patient survival.5
310861892019TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.12
311514152019Case reports: novel TUBG1 mutations with milder neurodevelopmental presentations.7

Citation

Dessen P

TUBG1 (tubulin gamma 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50980/tubg1-(tubulin-gamma-1)