ACKR4 (atypical chemokine receptor 4)

2009-08-01  

Identity

HGNC
ACKR4
LOCATION
3q22.1
LOCUSID
51554
ALIAS
CC-CKR-11,CCBP2,CCR-11,CCR10,CCR11,CCRL1,CCX

Other Information

Locus ID:

NCBI: 51554
MIM: 606065
HGNC: 1611
Ensembl: ENSG00000129048

Variants:

dbSNP: 51554
ClinVar: 51554
TCGA: ENSG00000129048
COSMIC: ACKR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129048ENST00000249887Q9NPB9
ENSG00000129048ENST00000509820H0Y9Z2

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
Chemokine receptors bind chemokinesREACTOMER-HSA-380108

References

Pubmed IDYearTitleCitations
385972172024Atypical chemokine receptor 4 (ACKR4/CCX-CKR): A comprehensive exploration across physiological and pathological landscapes in contemporary research.0
385972172024Atypical chemokine receptor 4 (ACKR4/CCX-CKR): A comprehensive exploration across physiological and pathological landscapes in contemporary research.0
374491982023Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension.1
374491982023Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension.1
351085382022Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.7
351085382022Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics.7
324804262021Systematic reassessment of chemokine-receptor pairings confirms CCL20 but not CXCL13 and extends the spectrum of ACKR4 agonists to CCL22.6
341021932021The relation between ACKR4 and CCR7 genes expression and breast cancer metastasis.6
324804262021Systematic reassessment of chemokine-receptor pairings confirms CCL20 but not CXCL13 and extends the spectrum of ACKR4 agonists to CCL22.6
341021932021The relation between ACKR4 and CCR7 genes expression and breast cancer metastasis.6
323910182020ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins.27
325336382020CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.14
333747922020Biphasic Expression of Atypical Chemokine Receptor (ACKR) 2 and ACKR4 in Colorectal Neoplasms in Association with Histopathological Findings.6
323910182020ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins.27
325336382020CCL20 is a novel ligand for the scavenging atypical chemokine receptor 4.14

Citation

Dessen P

ACKR4 (atypical chemokine receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51003/ackr4-(atypical-chemokine-receptor-4)