ASRGL1 (asparaginase and isoaspartyl peptidase 1)

2009-08-01  

Identity

HGNC
LOCATION
11q12.3
LOCUSID
ALIAS
ALP,ALP1,CRASH
FUSION GENES

Other Information

Locus ID:

NCBI: 80150
MIM: 609212
HGNC: 16448
Ensembl: ENSG00000162174

Variants:

dbSNP: 80150
ClinVar: 80150
TCGA: ENSG00000162174
COSMIC: ASRGL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000162174ENST00000301776Q7L266
ENSG00000162174ENST00000301776A0A024R573
ENSG00000162174ENST00000415229Q7L266
ENSG00000162174ENST00000415229A0A024R573
ENSG00000162174ENST00000526096A0A087WZI5
ENSG00000162174ENST00000528206A0A087X1T8
ENSG00000162174ENST00000529226E9PJK6
ENSG00000162174ENST00000534183E9PJK6
ENSG00000162174ENST00000534571A0A087WUG3
ENSG00000162174ENST00000628829E9PJK6

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Phenylalanine and tyrosine catabolismREACTOMER-HSA-71182
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198396452009The human asparaginase-like protein 1 hASRGL1 is an Ntn hydrolase with beta-aspartyl peptidase activity.22
119848342002A novel asparaginase-like protein is a sperm autoantigen in rats.11
271061002016A missense mutation in ASRGL1 is involved in causing autosomal recessive retinal degeneration.8
296846832018Brain-related proteins as potential CSF biomarkers of Alzheimer's disease: A targeted mass spectrometry approach.8
194143322009Cell growth stimulation by CRASH, an asparaginase-like protein overexpressed in human tumors and metastatic breast cancers.7
258586962015Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma.7
228917682012Uncoupling intramolecular processing and substrate hydrolysis in the N-terminal nucleophile hydrolase hASRGL1 by circular permutation.5
290968822018Asparaginase-like protein 1 is an independent prognostic marker in primary endometrial cancer, and is frequently lost in metastatic lesions.3
294869922018Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma.2
267806882016Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages.1

Citation

Dessen P

ASRGL1 (asparaginase and isoaspartyl peptidase 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51011/asrgl1-(asparaginase-and-isoaspartyl-peptidase-1)