FLOT1 (flotillin 1)

2009-08-01  

Identity

HGNC
LOCATION
6p21.33
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 10211
MIM: 606998
HGNC: 3757
Ensembl: ENSG00000137312

Variants:

dbSNP: 10211
ClinVar: 10211
TCGA: ENSG00000137312
COSMIC: FLOT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137312ENST00000376389O75955
ENSG00000137312ENST00000376389Q5ST80
ENSG00000137312ENST00000413165A2AB09
ENSG00000137312ENST00000416018A2AB11
ENSG00000137312ENST00000418160A2ABJ5
ENSG00000137312ENST00000438162A2AB10
ENSG00000137312ENST00000445853A2AB12
ENSG00000137312ENST00000454845A2AB13

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450

Pathways

PathwaySourceExternal ID
Insulin signaling pathwayKEGGko04910
Insulin signaling pathwayKEGGhsa04910
Neuronal SystemREACTOMER-HSA-112316
SALM protein interactions at the synapsesREACTOMER-HSA-8849932
Protein-protein interactions at synapsesREACTOMER-HSA-6794362

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
383744062024Flotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities.0
386860572024Circ_0003855 involvement of esophageal cancer progression through miR-622/FLOT1.1
383744062024Flotillin-1 palmitoylation is essential for its stability and subsequent tumor promoting capabilities.0
386860572024Circ_0003855 involvement of esophageal cancer progression through miR-622/FLOT1.1
366477002023Flotillin-1 is a prognostic biomarker for glioblastoma and promotes cancer development through enhancing invasion and altering tumour microenvironment.3
366918292023Lipid raft protein flotillin-1 is important for the interaction between SOS1 and H-Ras/K-Ras, leading to Ras activation.1
366979542023FLOT1 knockdown inhibits growth of AML cells through triggering apoptosis and pyroptosis.0
370110052023EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma.3
377723852023The roles of FLOT1 in human diseases (Review).6
379282692023FLOT1 promotes gastric cancer progression and metastasis through BCAR1/ERK signaling.0
366477002023Flotillin-1 is a prognostic biomarker for glioblastoma and promotes cancer development through enhancing invasion and altering tumour microenvironment.3
366918292023Lipid raft protein flotillin-1 is important for the interaction between SOS1 and H-Ras/K-Ras, leading to Ras activation.1
366979542023FLOT1 knockdown inhibits growth of AML cells through triggering apoptosis and pyroptosis.0
370110052023EIF4A3 Acts on the PI3K-AKT-ERK1/2-P70S6K Pathway through FLOT1 to Influence the Development of Lung Adenocarcinoma.3
377723852023The roles of FLOT1 in human diseases (Review).6

Citation

Dessen P

FLOT1 (flotillin 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51013/flot1