GALNT1 (polypeptide N-acetylgalactosaminyltransferase 1)

2009-08-01  

Identity

HGNC
LOCATION
18q12.2
LOCUSID
ALIAS
GALNAC-T1
FUSION GENES

Other Information

Locus ID:

NCBI: 2589
MIM: 602273
HGNC: 4123
Ensembl: ENSG00000141429

Variants:

dbSNP: 2589
ClinVar: 2589
TCGA: ENSG00000141429
COSMIC: GALNT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141429ENST00000269195Q10472
ENSG00000141429ENST00000269195A0A024RC48
ENSG00000141429ENST00000589189K7EJV8
ENSG00000141429ENST00000590654K7EK46
ENSG00000141429ENST00000591081Q10472
ENSG00000141429ENST00000591924Q10472

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Mucin type O-glycan biosynthesisKEGGko00512
Mucin type O-glycan biosynthesisKEGGhsa00512
Metabolic pathwaysKEGGhsa01100
O-glycan biosynthesis, mucin type coreKEGGhsa_M00056
O-glycan biosynthesis, mucin type coreKEGGM00056
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-independent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811436

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
364398762022GALNT1 Enhances Malignant Phenotype of Gastric Cancer via Modulating CD44 Glycosylation to Activate the Wnt/β-catenin Signaling Pathway.5
364398762022GALNT1 Enhances Malignant Phenotype of Gastric Cancer via Modulating CD44 Glycosylation to Activate the Wnt/β-catenin Signaling Pathway.5
318368472020LAMTOR5 raises abnormal initiation of O-glycosylation in breast cancer metastasis via modulating GALNT1 activity.16
332847882020High Expression of N-Acetylgalactosaminyl-transferase 1 (GALNT1) Associated with Invasion, Metastasis, and Proliferation in Osteosarcoma.5
318368472020LAMTOR5 raises abnormal initiation of O-glycosylation in breast cancer metastasis via modulating GALNT1 activity.16
332847882020High Expression of N-Acetylgalactosaminyl-transferase 1 (GALNT1) Associated with Invasion, Metastasis, and Proliferation in Osteosarcoma.5
299153112018LncRNA SNHG7 sponges miR-216b to promote proliferation and liver metastasis of colorectal cancer through upregulating GALNT1.99
303897892018Site-specific glycosylation of Ebola virus glycoprotein by human polypeptide GalNAc-transferase 1 induces cell adhesion defects.14
299153112018LncRNA SNHG7 sponges miR-216b to promote proliferation and liver metastasis of colorectal cancer through upregulating GALNT1.99
303897892018Site-specific glycosylation of Ebola virus glycoprotein by human polypeptide GalNAc-transferase 1 induces cell adhesion defects.14
279135702017Revisiting the human polypeptide GalNAc-T1 and T13 paralogs.11
281882502017MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts.30
279135702017Revisiting the human polypeptide GalNAc-T1 and T13 paralogs.11
281882502017MiR30-GALNT1/2 Axis-Mediated Glycosylation Contributes to the Increased Secretion of Inactive Human Prohormone for Brain Natriuretic Peptide (proBNP) From Failing Hearts.30
266767482016GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells.45

Citation

Dessen P

GALNT1 (polypeptide N-acetylgalactosaminyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51033/galnt1-(polypeptide-n-acetylgalactosaminyltransferase-1)