DESI2 (desumoylating isopeptidase 2)

2009-08-01  

Identity

HGNC
DESI2
LOCATION
1q44
LOCUSID
51029
ALIAS
C1orf121,CGI-146,DESI,DESI1,DeSI-2,FAM152A,PNAS-4,PPPDE1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51029
MIM: 614638
HGNC: 24264
Ensembl: ENSG00000121644

Variants:

dbSNP: 51029
ClinVar: 51029
TCGA: ENSG00000121644
COSMIC: DESI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121644ENST00000263831Q9BSY9
ENSG00000121644ENST00000263831A0A024R5P9
ENSG00000121644ENST00000302550Q9BSY9
ENSG00000121644ENST00000302550A0A024R5P6
ENSG00000121644ENST00000418162B1APK7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
304112972019Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway.2
304262802019PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis.7
304112972019Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway.2
304262802019PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis.7
300551352018Combination of DESI2 and endostatin gene therapy significantly improves antitumor efficacy by accumulating DNA lesions, inducing apoptosis and inhibiting angiogenesis.3
300551352018Combination of DESI2 and endostatin gene therapy significantly improves antitumor efficacy by accumulating DNA lesions, inducing apoptosis and inhibiting angiogenesis.3
284835202017PPPDE1 is a novel deubiquitinase belonging to a cysteine isopeptidase family.10
284835202017PPPDE1 is a novel deubiquitinase belonging to a cysteine isopeptidase family.10
250793762015High Phosphorylation Status of AKT/mTOR Signal in DESI2-Reduced Pancreatic Ductal Adenocarcinoma.2
259181612015PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells.12
250793762015High Phosphorylation Status of AKT/mTOR Signal in DESI2-Reduced Pancreatic Ductal Adenocarcinoma.2
259181612015PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells.12
233220882013hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells.6
233220882013hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells.6
215567702012PNAS-4 expression and its relationship to p53 in colorectal cancer.1

Citation

Dessen P

DESI2 (desumoylating isopeptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51034/desi2-(desumoylating-isopeptidase-2)