DESI2 (desumoylating isopeptidase 2)

2009-08-01  

Identity

HGNC
LOCATION
1q44
LOCUSID
ALIAS
C1orf121,CGI-146,DESI,DESI1,DeSI-2,FAM152A,PNAS-4,PPPDE1
FUSION GENES

Other Information

Locus ID:

NCBI: 51029
MIM: 614638
HGNC: 24264
Ensembl: ENSG00000121644

Variants:

dbSNP: 51029
ClinVar: 51029
TCGA: ENSG00000121644
COSMIC: DESI2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121644ENST00000263831Q9BSY9
ENSG00000121644ENST00000263831A0A024R5P9
ENSG00000121644ENST00000302550Q9BSY9
ENSG00000121644ENST00000302550A0A024R5P6
ENSG00000121644ENST00000418162B1APK7

Expression (GTEx)

0
10
20
30
40
50
60

References

Pubmed IDYearTitleCitations
259181612015PNAS-4, an Early DNA Damage Response Gene, Induces S Phase Arrest and Apoptosis by Activating Checkpoint Kinases in Lung Cancer Cells.10
191333122009A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice.7
233220882013hPNAS-4 inhibits proliferation through S phase arrest and apoptosis: underlying action mechanism in ovarian cancer cells.5
304262802019PPPDE1 promotes hepatocellular carcinoma development by negatively regulate p53 and apoptosis.3
250793762015High Phosphorylation Status of AKT/mTOR Signal in DESI2-Reduced Pancreatic Ductal Adenocarcinoma.2
215567702012PNAS-4 expression and its relationship to p53 in colorectal cancer.1
284835202017PPPDE1 is a novel deubiquitinase belonging to a cysteine isopeptidase family.0
300551352018Combination of DESI2 and endostatin gene therapy significantly improves antitumor efficacy by accumulating DNA lesions, inducing apoptosis and inhibiting angiogenesis.0
304112972019Desumoylating Isopeptidase 2 (DESI2) Inhibits Proliferation and Promotes Apoptosis of Pancreatic Cancer Cells through Regulating PI3K/AKT/mTOR Signaling Pathway.0

Citation

Dessen P

DESI2 (desumoylating isopeptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51034/desi2-(desumoylating-isopeptidase-2)