APOC3 (apolipoprotein C3)

2009-08-01  

Identity

HGNC
APOC3
LOCATION
11q23.3
LOCUSID
345
ALIAS
APOCIII
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 345
MIM: 107720
HGNC: 610
Ensembl: ENSG00000110245

Variants:

dbSNP: 345
ClinVar: 345
TCGA: ENSG00000110245
COSMIC: APOC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110245ENST00000227667P02656
ENSG00000110245ENST00000227667A3KPE2
ENSG00000110245ENST00000375345B0YIW2
ENSG00000110245ENST00000433777C9J2Q0
ENSG00000110245ENST00000630701B0YIW2

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
7000
8000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PPAR signaling pathwayKEGGko03320
PPAR signaling pathwayKEGGhsa03320
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
Chylomicron-mediated lipid transportREACTOMER-HSA-174800
HDL-mediated lipid transportREACTOMER-HSA-194223
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164742099MTTPGenePathwayassociated
PA444528HyperlipidemiasDiseaseClinicalAnnotationassociatedPD15809899
PA447230HIV InfectionsDiseaseClinicalAnnotation, VariantAnnotationassociatedPD15809899
PA451260ritonavirChemicalClinicalAnnotation, VariantAnnotationassociatedPD15809899

References

Pubmed IDYearTitleCitations
379727312024Apolipoprotein C3: form begets function.2
380393512024Exploring apolipoprotein C-III: pathophysiological and pharmacological relevance.1
382325382024Apolipoprotein C3 (ApoC3) facilitates NLRP3 mediated pyroptosis of macrophages through mitochondrial damage by accelerating of the interaction between SCIMP and SYK pathway in acute lung injury.0
387914052024Apolipoprotein-CIII O-Glycosylation Is Associated with Micro- and Macrovascular Complications of Type 2 Diabetes.0
379727312024Apolipoprotein C3: form begets function.2
380393512024Exploring apolipoprotein C-III: pathophysiological and pharmacological relevance.1
382325382024Apolipoprotein C3 (ApoC3) facilitates NLRP3 mediated pyroptosis of macrophages through mitochondrial damage by accelerating of the interaction between SCIMP and SYK pathway in acute lung injury.0
387914052024Apolipoprotein-CIII O-Glycosylation Is Associated with Micro- and Macrovascular Complications of Type 2 Diabetes.0
366890702023APOC-III: a Gatekeeper in Controlling Triglyceride Metabolism.8
368551142023Apolipoprotein C3 is negatively associated with estrogen and mediates the protective effect of estrogen on hypertriglyceridemia in obese adults.1
368763642023APOC3 and ABCA1 variants in unusual combined hypolipidaemia showing premature peripheral vascular disease.0
369211962023Investigation of associations between apolipoprotein A5 and C3 gene polymorphisms with plasma triglyceride and lipid levels.0
370442042023Role of APOC3 3238C/G polymorphism in HIV-associated neurocognitive disorder.0
378669582023[Association Between Apolipoprotein C-3 SstⅠ Polymorphism and Serum Lipids in Patients With Gestational Diabetes Mellitus].1
379020172023SP1 transcriptionally upregulates the expression of APOC3 in KGN cells to promote disease progression by regulating TLR2/NF-κB signalling pathway.0

Citation

Dessen P

APOC3 (apolipoprotein C3)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51037/apoc3-(apolipoprotein-c3)