ATG5 (autophagy related 5)

2009-08-01  

Identity

HGNC
ATG5
LOCATION
6q21
LOCUSID
9474
ALIAS
APG5,APG5-LIKE,APG5L,ASP,SCAR25,hAPG5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9474
MIM: 604261
HGNC: 589
Ensembl: ENSG00000057663

Variants:

dbSNP: 9474
ClinVar: 9474
TCGA: ENSG00000057663
COSMIC: ATG5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000057663ENST00000343245Q9H1Y0
ENSG00000057663ENST00000343245A9UGY9
ENSG00000057663ENST00000360666Q7Z3H3
ENSG00000057663ENST00000369070L7UMD8
ENSG00000057663ENST00000369076Q9H1Y0
ENSG00000057663ENST00000369076A9UGY9
ENSG00000057663ENST00000613993L7UQJ2
ENSG00000057663ENST00000635758Q9H1Y0
ENSG00000057663ENST00000636335A0A1B0GUS1
ENSG00000057663ENST00000636437A0A1B0GV54
ENSG00000057663ENST00000646025A0A2R8Y718

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
ShigellosisKEGGhsa05131
RIG-I-like receptor signaling pathwayKEGGko04622
RIG-I-like receptor signaling pathwayKEGGhsa04622
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysREACTOMER-HSA-168928
Negative regulators of RIG-I/MDA5 signalingREACTOMER-HSA-936440
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
MitophagyREACTOMER-HSA-5205647
Pink/Parkin Mediated MitophagyREACTOMER-HSA-5205685
Longevity regulating pathwayKEGGhsa04211
Longevity regulating pathway - multiple speciesKEGGko04213
Longevity regulating pathway - multiple speciesKEGGhsa04213
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137
Autophagy - otherKEGGko04136
FerroptosisKEGGko04216
Autophagy - otherKEGGhsa04136
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10004adalimumabChemicalClinicalAnnotationassociatedPD27096233
PA446116Inflammatory Bowel DiseasesDiseaseClinicalAnnotationassociatedPD27096233

References

Pubmed IDYearTitleCitations
379911292024Association of ATG16L1 and ATG5 gene polymorphisms with susceptibility to hepatitis B virus infection and progression to HCC in central China.0
380097082024Autophagy related gene 5 polymorphism rs17587319 (C/G) in asthmatic patients in North Indian population.0
383052852024MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage Polarization and Proliferation of Hepatocellular Carcinoma Cells.0
385117682024Serum autophagy-related gene 5 level in stroke patients: correlation with CD4+ T cells and cognition impairment during a 3-year follow-up.0
385307062024Autophagy-related 5 in acute ischemic stroke: Variation and linkage with neurofunction, and survival.0
387470162024Autophagy-related protein 5 (ATG5) interacts with bone marrow stromal cell antigen 2 (BST2) to stimulate HBV replication through antagonizing the antiviral activity of BST2.0
379911292024Association of ATG16L1 and ATG5 gene polymorphisms with susceptibility to hepatitis B virus infection and progression to HCC in central China.0
380097082024Autophagy related gene 5 polymorphism rs17587319 (C/G) in asthmatic patients in North Indian population.0
383052852024MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage Polarization and Proliferation of Hepatocellular Carcinoma Cells.0
385117682024Serum autophagy-related gene 5 level in stroke patients: correlation with CD4+ T cells and cognition impairment during a 3-year follow-up.0
385307062024Autophagy-related 5 in acute ischemic stroke: Variation and linkage with neurofunction, and survival.0
387470162024Autophagy-related protein 5 (ATG5) interacts with bone marrow stromal cell antigen 2 (BST2) to stimulate HBV replication through antagonizing the antiviral activity of BST2.0
368057972023Autophagy impairment in patients with obstructive sleep apnea modulates intermittent hypoxia-induced oxidative stress and cell apoptosis via hypermethylation of the ATG5 gene promoter region.3
369123052023Diagnostic Value of ATG5, Apo-Lipoprotein B-48, Thyroid Hormones, and Homocysteine in Patients with Alzheimer's Disease.1
370547062023ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion.8

Citation

Dessen P

ATG5 (autophagy related 5)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51040/atg5-(autophagy-related-5)