RAB11FIP3 (RAB11 family interacting protein 3)

2009-08-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
CART1,FIP3-Rab11,Rab11-FIP3
FUSION GENES

Other Information

Locus ID:

NCBI: 9727
MIM: 608738
HGNC: 17224
Ensembl: ENSG00000090565

Variants:

dbSNP: 9727
ClinVar: 9727
TCGA: ENSG00000090565
COSMIC: RAB11FIP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090565ENST00000262305O75154
ENSG00000090565ENST00000412256H0Y7F9
ENSG00000090565ENST00000434585X6RFI8
ENSG00000090565ENST00000449879A0A0A0MSV1
ENSG00000090565ENST00000450428O75154
ENSG00000090565ENST00000452814F6X994

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Cargo trafficking to the periciliary membraneREACTOMER-HSA-5620920
VxPx cargo-targeting to ciliumREACTOMER-HSA-5620916

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
156018962005The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.120
170308042006Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1.39
151584462004Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis.34
173944872007Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment.30
176282062007Molecular characterization of Rab11-FIP3 binding to ARF GTPases.25
202148882010Rab11-FIP3 binds dynein light intermediate chain 2 and its overexpression fragments the Golgi complex.23
256738792015The Arf and Rab11 effector FIP3 acts synergistically with ASAP1 to direct Rabin8 in ciliary receptor targeting.22
271542052016Rac1-Rab11-FIP3 regulatory hub coordinates vesicle traffic with actin remodeling and T-cell activation.21
193278672009Rab11-FIP3 is a Rab11-binding protein that regulates breast cancer cell motility by modulating the actin cytoskeleton.20
282151042017Increased Eps15 homology domain 1 and RAB11FIP3 expression regulate breast cancer progression via promoting epithelial growth factor receptor recycling.6

Citation

Dessen P

RAB11FIP3 (RAB11 family interacting protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51041/rab11fip3-(rab11-family-interacting-protein-3)