GIPR (gastric inhibitory polypeptide receptor)

2009-09-01  

Identity

HGNC
GIPR
LOCATION
19q13.32
LOCUSID
2696
ALIAS
PGQTL2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2696
MIM: 137241
HGNC: 4271
Ensembl: ENSG00000010310

Variants:

dbSNP: 2696
ClinVar: 2696
TCGA: ENSG00000010310
COSMIC: GIPR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000010310ENST00000263281P48546
ENSG00000010310ENST00000304207P48546
ENSG00000010310ENST00000585889K7EPD9
ENSG00000010310ENST00000590918P48546
ENSG00000010310ENST00000591322K7EJZ3
ENSG00000010310ENST00000652180A0A494C077

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD21747410, 25321336
PA450688olanzapineChemicalClinicalAnnotationassociatedPD21747410, 25321336

References

Pubmed IDYearTitleCitations
367745422023Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells.5
368827782023Association of gastric inhibitory polypeptide receptor (GIPR) gene polymorphism with type 2 diabetes mellitus in iranian patients.2
372982172023The Methylation Analysis of the Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Locus in GH-Secreting Pituitary Adenomas.0
367745422023Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells.5
368827782023Association of gastric inhibitory polypeptide receptor (GIPR) gene polymorphism with type 2 diabetes mellitus in iranian patients.2
372982172023The Methylation Analysis of the Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR) Locus in GH-Secreting Pituitary Adenomas.0
350650962022GLP-1 and GIP receptor signaling in beta cells - A review of receptor interactions and co-stimulation.22
361407022022The Link between Three Single Nucleotide Variants of the GIPR Gene and Metabolic Health.2
361777612022Differential effects of glucose-dependent insulinotropic polypeptide receptor/glucagon-like peptide-1 receptor heteromerization on cell signaling when expressed in HEK-293 cells.3
350650962022GLP-1 and GIP receptor signaling in beta cells - A review of receptor interactions and co-stimulation.22
361407022022The Link between Three Single Nucleotide Variants of the GIPR Gene and Metabolic Health.2
361777612022Differential effects of glucose-dependent insulinotropic polypeptide receptor/glucagon-like peptide-1 receptor heteromerization on cell signaling when expressed in HEK-293 cells.3
332909022021Targeting the GIPR for obesity: To agonize or antagonize? Potential mechanisms.40
338918642021Investigating GIPR (ant)agonism: A structural analysis of GIP and its receptor.7
344265082021Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region.9

Citation

Dessen P

GIPR (gastric inhibitory polypeptide receptor)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51056/gipr-(gastric-inhibitory-polypeptide-receptor)