TRIM62 (tripartite motif containing 62)

2009-09-01

Identity

HGNC

TRIM62

LOCATION

1p35.1

LOCUSID

55223

ALIAS

DEAR1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 55223
MIM: 616755
HGNC: 25574
Ensembl: ENSG00000116525

Variants:

dbSNP: 55223
ClinVar: 55223
TCGA: ENSG00000116525
COSMIC: TRIM62

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000116525	ENST00000291416	Q9BVG3
ENSG00000116525	ENST00000543586	Q9BVG3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Immune System	REACTOME	R-HSA-168256
Interferon gamma signaling	REACTOME	R-HSA-877300
Interferon Signaling	REACTOME	R-HSA-913531

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References

Pubmed ID	Year	Title	Citations
23402750	2013	Characterization of TRIM62 as a RING finger E3 ubiquitin ligase and its subcellular localization.	11
25248926	2015	Loss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemia.	23
25248926	2015	Loss of TRIM62 expression is an independent adverse prognostic factor in acute myeloid leukemia.	23
25261235	2014	DEAR1, a novel tumor suppressor that regulates cell polarity and epithelial plasticity.	16
25261235	2014	DEAR1, a novel tumor suppressor that regulates cell polarity and epithelial plasticity.	16
26488816	2015	Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.	62
26488816	2015	Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.	62
27793172	2016	Tripartite motif containing 62 is a novel prognostic marker and suppresses tumor metastasis via c-Jun/Slug signaling-mediated epithelial-mesenchymal transition in cervical cancer.	18
27793172	2016	Tripartite motif containing 62 is a novel prognostic marker and suppresses tumor metastasis via c-Jun/Slug signaling-mediated epithelial-mesenchymal transition in cervical cancer.	18
33093067	2020	USP15 Deubiquitinates CARD9 to Downregulate C-Type Lectin Receptor-Mediated Signaling.	5

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Citation

Dessen P

TRIM62 (tripartite motif containing 62)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51075