MCRS1 (microspherule protein 1)

2009-09-01  

Identity

HGNC
LOCATION
12q13.12
LOCUSID
ALIAS
ICP22BP,INO80Q,MCRS2,MSP58,P78
FUSION GENES

Other Information

Locus ID:

NCBI: 10445
MIM: 609504
HGNC: 6960
Ensembl: ENSG00000187778

Variants:

dbSNP: 10445
ClinVar: 10445
TCGA: ENSG00000187778
COSMIC: MCRS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187778ENST00000343810Q96EZ8
ENSG00000187778ENST00000357123Q96EZ8
ENSG00000187778ENST00000546244Q96EZ8
ENSG00000187778ENST00000546244A0A024R134
ENSG00000187778ENST00000548334F8VP44
ENSG00000187778ENST00000548596F8VVA6
ENSG00000187778ENST00000548602F8VZC2
ENSG00000187778ENST00000548646H0YI67
ENSG00000187778ENST00000549528F8W0I9
ENSG00000187778ENST00000550165Q96EZ8
ENSG00000187778ENST00000551598H0YIA0
ENSG00000187778ENST00000553173F8W126

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DNA RepairREACTOMER-HSA-73894
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
220810942011K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly.38
119481832002Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration.31
165716022014The two mRNA transcription variants of the B-cell activating factor are differentially expressed, but in a stable ratio.26
161861062005Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription.23
253733882014MCRS1 overexpression, which is specifically inhibited by miR-129*, promotes the epithelial-mesenchymal transition and metastasis in non-small cell lung cancer.23
195492532009Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway.20
165474912006p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability.15
170148432006DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription.13
22563078201258-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.13
232253322013Analysis of 20 genes at chromosome band 12q13: RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer.12

Citation

Dessen P

MCRS1 (microspherule protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51076/mcrs1-(microspherule-protein-1)