RIF1 (replication timing regulatory factor 1)

2009-09-01  

Identity

HGNC
LOCATION
2q23.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 55183
MIM: 608952
HGNC: 23207
Ensembl: ENSG00000080345

Variants:

dbSNP: 55183
ClinVar: 55183
TCGA: ENSG00000080345
COSMIC: RIF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000080345ENST00000243326Q5UIP0
ENSG00000080345ENST00000414861H7BZN3
ENSG00000080345ENST00000428287Q5UIP0
ENSG00000080345ENST00000430328Q5UIP0
ENSG00000080345ENST00000444746Q5UIP0
ENSG00000080345ENST00000453091Q5UIP0
ENSG00000080345ENST00000454583H7C2B5

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Signaling pathways regulating pluripotency of stem cellsKEGGhsa04550
Signaling pathways regulating pluripotency of stem cellsKEGGko04550
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Nonhomologous End-Joining (NHEJ)REACTOMER-HSA-5693571

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
375489402024Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer.0
382449282024Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer.4
375489402024Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer.0
382449282024Longitudinal profiling identifies co-occurring BRCA1/2 reversions, TP53BP1, RIF1 and PAXIP1 mutations in PARP inhibitor-resistant advanced breast cancer.4
367197982023RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1.2
374379292023MiR-30a-5p Enhances Cisplatin Sensitivity by Downregulating RIF1 in Ovarian Cancer.2
367197982023RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1.2
374379292023MiR-30a-5p Enhances Cisplatin Sensitivity by Downregulating RIF1 in Ovarian Cancer.2
351776092022RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.6
353281022022Rif1-Dependent Control of Replication Timing.10
354723312022Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells.7
351776092022RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity.6
353281022022Rif1-Dependent Control of Replication Timing.10
354723312022Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells.7
336746262021Variants in NEB and RIF1 genes on chr2q23 are associated with skeletal muscle index in Koreans: genome-wide association study.2

Citation

Dessen P

RIF1 (replication timing regulatory factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51082/rif1-(replication-timing-regulatory-factor-1)