LBX1 (ladybird homeobox 1)

2009-09-01  

Identity

HGNC
LBX1
LOCATION
10q24.32
LOCUSID
10660
ALIAS
HPX-6,HPX6,LBX1H,homeobox

Other Information

Locus ID:

NCBI: 10660
MIM: 604255
HGNC: 16960
Ensembl: ENSG00000138136

Variants:

dbSNP: 10660
ClinVar: 10660
TCGA: ENSG00000138136
COSMIC: LBX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138136ENST00000370193P52954

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
220197792011A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis.70
196519852009A developmentally regulated inducer of EMT, LBX1, contributes to breast cancer progression.45
223014632012SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese.19
247218342014A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups.19
259871912015Candidate gene analysis and exome sequencing confirm LBX1 as a susceptibility gene for idiopathic scoliosis.16
230962522013Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population.14
233081682013Association between common variants near LBX1 and adolescent idiopathic scoliosis replicated in the Chinese Han population.14
268201552016Functional Investigation of a Non-coding Variant Associated with Adolescent Idiopathic Scoliosis in Zebrafish: Elevated Expression of the Ladybird Homeobox Gene Causes Body Axis Deformation.13
256754282015Haplotypes at LBX1 have distinct inheritance patterns with opposite effects in adolescent idiopathic scoliosis.8
274505932016Associations of LBX1 gene and adolescent idiopathic scoliosis susceptibility: a meta-analysis based on 34,626 subjects.7

Citation

Dessen P

LBX1 (ladybird homeobox 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51096/lbx1-(ladybird-homeobox-1)