LSAMP (limbic system associated membrane protein)

2009-09-01 Affiliation

Identity

HGNC

LSAMP

LOCATION

3q13.31

LOCUSID

4045

ALIAS

IGLON3,LAMP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4045
MIM: 603241
HGNC: 6705
Ensembl: ENSG00000185565

Variants:

dbSNP: 4045
ClinVar: 4045
TCGA: ENSG00000185565
COSMIC: LSAMP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000185565	ENST00000333617	H3BLU2
ENSG00000185565	ENST00000474851	C9J5G3
ENSG00000185565	ENST00000490035	Q13449
ENSG00000185565	ENST00000539563	F5H5G1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteins	REACTOME	R-HSA-163125

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA447199	Bipolar Disorder	Disease	Literature, MultilinkAnnotation	associated			24718920

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
18268500	2009	Proteomic analysis of membrane microdomain-associated proteins in the dorsolateral prefrontal cortex in schizophrenia and bipolar disorder reveals alterations in LAMP, STXBP1 and BASP1 protein expression.	55
19441093	2009	LSAMP, a novel candidate tumor suppressor gene in human osteosarcomas, identified by array comparative genomic hybridization.	31
27693347	2017	Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease.	24
26844274	2015	A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men.	23
19724913	2009	Identification of chromosomal aberrations associated with disease progression and a novel 3q13.31 deletion involving LSAMP gene in osteosarcoma.	15
18318786	2008	Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease.	12
18318786	2008	Polymorphisms of the tumor suppressor gene LSAMP are associated with left main coronary artery disease.	12
22892717	2012	Associations between LSAMP gene polymorphisms and major depressive disorder and panic disorder.	12
18433483	2008	Association of limbic system-associated membrane protein (LSAMP) to male completed suicide.	9

Citation

Dessen P

LSAMP (limbic system associated membrane protein)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51101/lsamp-(limbic-system-associated-membrane-protein)